2BI4
Lactaldehyde:1,2-propanediol oxidoreductase of Escherichia coli
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006004 | biological_process | fucose metabolic process |
| A | 0008198 | molecular_function | ferrous iron binding |
| A | 0008912 | molecular_function | lactaldehyde reductase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019301 | biological_process | rhamnose catabolic process |
| A | 0019317 | biological_process | fucose catabolic process |
| A | 0042355 | biological_process | L-fucose catabolic process |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0042846 | biological_process | glycol catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052660 | molecular_function | R-lactaldehyde reductase activity |
| A | 0052661 | molecular_function | S-lactaldehyde reductase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004022 | molecular_function | alcohol dehydrogenase (NAD+) activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006004 | biological_process | fucose metabolic process |
| B | 0008198 | molecular_function | ferrous iron binding |
| B | 0008912 | molecular_function | lactaldehyde reductase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019301 | biological_process | rhamnose catabolic process |
| B | 0019317 | biological_process | fucose catabolic process |
| B | 0042355 | biological_process | L-fucose catabolic process |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0042846 | biological_process | glycol catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052660 | molecular_function | R-lactaldehyde reductase activity |
| B | 0052661 | molecular_function | S-lactaldehyde reductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE A1384 |
| Chain | Residue |
| A | ASP196 |
| A | HIS200 |
| A | HIS263 |
| A | HIS277 |
| A | ASN281 |
| A | NAD1385 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 500 |
| Chain | Residue |
| A | LYS33 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE B2384 |
| Chain | Residue |
| B | HIS1263 |
| B | HIS1277 |
| B | ASN1281 |
| B | NAD2385 |
| B | ASP1196 |
| B | HIS1200 |
| site_id | AC4 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE NAD A1385 |
| Chain | Residue |
| A | ASP39 |
| A | THR41 |
| A | LEU42 |
| A | GLY97 |
| A | GLY98 |
| A | SER99 |
| A | THR140 |
| A | THR141 |
| A | THR144 |
| A | VAL153 |
| A | LYS162 |
| A | MET181 |
| A | GLY184 |
| A | MET185 |
| A | LEU189 |
| A | ASP196 |
| A | HIS200 |
| A | PHE254 |
| A | LEU259 |
| A | HIS263 |
| A | HIS277 |
| A | FE1384 |
| B | ASP1342 |
| site_id | AC5 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE NAD B2385 |
| Chain | Residue |
| A | ASP342 |
| B | ASP1039 |
| B | THR1041 |
| B | LEU1042 |
| B | ASN1071 |
| B | GLY1097 |
| B | GLY1098 |
| B | SER1099 |
| B | PRO1100 |
| B | THR1140 |
| B | THR1141 |
| B | THR1144 |
| B | ASN1151 |
| B | VAL1153 |
| B | LYS1162 |
| B | MET1181 |
| B | GLY1184 |
| B | MET1185 |
| B | LEU1189 |
| B | ASP1196 |
| B | HIS1200 |
| B | PHE1254 |
| B | HIS1263 |
| B | HIS1277 |
| B | FE2384 |
Functional Information from PROSITE/UniProt
| site_id | PS00060 |
| Number of Residues | 21 |
| Details | ADH_IRON_2 Iron-containing alcohol dehydrogenases signature 2. GlVHgmAHpLGAfynTpHGvA |
| Chain | Residue | Details |
| A | GLY260-ALA280 |
| site_id | PS00913 |
| Number of Residues | 29 |
| Details | ADH_IRON_1 Iron-containing alcohol dehydrogenases signature 1. AFiDadmmdgmPpalkAaTgvDALthaiE |
| Chain | Residue | Details |
| A | ALA175-GLU203 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 30 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"2BI4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BL4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5BR4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"2BI4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BL4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"2BL4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5BR4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"1RRM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BI4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BL4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5BR4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dqs |
| Chain | Residue | Details |
| A | HIS267 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dqs |
| Chain | Residue | Details |
| B | HIS1267 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dqs |
| Chain | Residue | Details |
| A | HIS263 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dqs |
| Chain | Residue | Details |
| B | HIS1263 |
