2BHT
Crystal structure of O-acetylserine sulfhydrylase B
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004124 | molecular_function | cysteine synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006535 | biological_process | L-cysteine biosynthetic process from L-serine |
| A | 0016226 | biological_process | iron-sulfur cluster assembly |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019344 | biological_process | L-cysteine biosynthetic process |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0044272 | biological_process | sulfur compound biosynthetic process |
| A | 0080146 | molecular_function | L-cysteine desulfhydrase activity |
| B | 0004124 | molecular_function | cysteine synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006535 | biological_process | L-cysteine biosynthetic process from L-serine |
| B | 0016226 | biological_process | iron-sulfur cluster assembly |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019344 | biological_process | L-cysteine biosynthetic process |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0044272 | biological_process | sulfur compound biosynthetic process |
| B | 0080146 | molecular_function | L-cysteine desulfhydrase activity |
| C | 0004124 | molecular_function | cysteine synthase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006535 | biological_process | L-cysteine biosynthetic process from L-serine |
| C | 0016226 | biological_process | iron-sulfur cluster assembly |
| C | 0016829 | molecular_function | lyase activity |
| C | 0019344 | biological_process | L-cysteine biosynthetic process |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0044272 | biological_process | sulfur compound biosynthetic process |
| C | 0080146 | molecular_function | L-cysteine desulfhydrase activity |
| D | 0004124 | molecular_function | cysteine synthase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006535 | biological_process | L-cysteine biosynthetic process from L-serine |
| D | 0016226 | biological_process | iron-sulfur cluster assembly |
| D | 0016829 | molecular_function | lyase activity |
| D | 0019344 | biological_process | L-cysteine biosynthetic process |
| D | 0030170 | molecular_function | pyridoxal phosphate binding |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 0044272 | biological_process | sulfur compound biosynthetic process |
| D | 0080146 | molecular_function | L-cysteine desulfhydrase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PLP A 320 |
| Chain | Residue |
| A | LYS41 |
| A | GLY208 |
| A | SER255 |
| A | CYS280 |
| A | TYR286 |
| A | HOH2015 |
| A | ASN71 |
| A | SER172 |
| A | MET173 |
| A | GLY174 |
| A | THR175 |
| A | THR176 |
| A | GLY177 |
| A | THR178 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PLP B 320 |
| Chain | Residue |
| B | LYS41 |
| B | ASN71 |
| B | SER172 |
| B | MET173 |
| B | GLY174 |
| B | THR175 |
| B | THR176 |
| B | GLY177 |
| B | THR178 |
| B | GLY208 |
| B | ILE209 |
| B | SER255 |
| B | TYR286 |
| B | HOH2010 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE PLP C 320 |
| Chain | Residue |
| C | LYS41 |
| C | ASN71 |
| C | SER172 |
| C | MET173 |
| C | GLY174 |
| C | THR175 |
| C | THR176 |
| C | GLY177 |
| C | THR178 |
| C | PRO207 |
| C | GLY208 |
| C | ILE209 |
| C | SER255 |
| C | ASP281 |
| C | HOH2009 |
| C | HOH2010 |
| C | HOH2036 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PLP D 320 |
| Chain | Residue |
| D | VAL40 |
| D | LYS41 |
| D | GLY174 |
| D | THR175 |
| D | THR176 |
| D | GLY177 |
| D | THR178 |
| D | SER255 |
| D | CYS280 |
| D | TYR286 |
| D | HOH2014 |
| D | HOH2015 |
Functional Information from PROSITE/UniProt
| site_id | PS00901 |
| Number of Residues | 19 |
| Details | CYS_SYNTHASE Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. KlEgnn.PAgSVKdRaAlsM |
| Chain | Residue | Details |
| A | LYS30-MET48 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15952768","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oas |
| Chain | Residue | Details |
| A | SER255 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oas |
| Chain | Residue | Details |
| B | SER255 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oas |
| Chain | Residue | Details |
| C | SER255 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oas |
| Chain | Residue | Details |
| D | SER255 |
