Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2BHS

Crystal Structure of Cysteine Synthase B

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004124	molecular_function	cysteine synthase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006535	biological_process	cysteine biosynthetic process from serine
A	0008652	biological_process	amino acid biosynthetic process
A	0016226	biological_process	iron-sulfur cluster assembly
A	0016740	molecular_function	transferase activity
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
A	0016829	molecular_function	lyase activity
A	0019344	biological_process	cysteine biosynthetic process
A	0019345	biological_process	cysteine biosynthetic process via S-sulfo-L-cysteine
A	0019450	biological_process	L-cysteine catabolic process to pyruvate
A	0030170	molecular_function	pyridoxal phosphate binding
A	0042803	molecular_function	protein homodimerization activity
A	0080146	molecular_function	L-cysteine desulfhydrase activity
B	0004124	molecular_function	cysteine synthase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006535	biological_process	cysteine biosynthetic process from serine
B	0008652	biological_process	amino acid biosynthetic process
B	0016226	biological_process	iron-sulfur cluster assembly
B	0016740	molecular_function	transferase activity
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0016829	molecular_function	lyase activity
B	0019344	biological_process	cysteine biosynthetic process
B	0019345	biological_process	cysteine biosynthetic process via S-sulfo-L-cysteine
B	0019450	biological_process	L-cysteine catabolic process to pyruvate
B	0030170	molecular_function	pyridoxal phosphate binding
B	0042803	molecular_function	protein homodimerization activity
B	0080146	molecular_function	L-cysteine desulfhydrase activity
C	0004124	molecular_function	cysteine synthase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0006535	biological_process	cysteine biosynthetic process from serine
C	0008652	biological_process	amino acid biosynthetic process
C	0016226	biological_process	iron-sulfur cluster assembly
C	0016740	molecular_function	transferase activity
C	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
C	0016829	molecular_function	lyase activity
C	0019344	biological_process	cysteine biosynthetic process
C	0019345	biological_process	cysteine biosynthetic process via S-sulfo-L-cysteine
C	0019450	biological_process	L-cysteine catabolic process to pyruvate
C	0030170	molecular_function	pyridoxal phosphate binding
C	0042803	molecular_function	protein homodimerization activity
C	0080146	molecular_function	L-cysteine desulfhydrase activity
D	0004124	molecular_function	cysteine synthase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0006535	biological_process	cysteine biosynthetic process from serine
D	0008652	biological_process	amino acid biosynthetic process
D	0016226	biological_process	iron-sulfur cluster assembly
D	0016740	molecular_function	transferase activity
D	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
D	0016829	molecular_function	lyase activity
D	0019344	biological_process	cysteine biosynthetic process
D	0019345	biological_process	cysteine biosynthetic process via S-sulfo-L-cysteine
D	0019450	biological_process	L-cysteine catabolic process to pyruvate
D	0030170	molecular_function	pyridoxal phosphate binding
D	0042803	molecular_function	protein homodimerization activity
D	0080146	molecular_function	L-cysteine desulfhydrase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE PLP A 320

Chain	Residue
A	LYS41
A	ILE209
A	SER255
A	CYS280
A	ASP281
A	TYR286
A	HOH2043
A	HOH2070
A	HOH2071
A	HOH2072
A	ASN71
A	SER172
A	GLY174
A	THR175
A	THR176
A	GLY177
A	THR178
A	GLY208

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE PLP B 320

Chain	Residue
B	LYS41
B	ASN71
B	SER172
B	GLY174
B	THR175
B	THR176
B	GLY177
B	THR178
B	GLY208
B	ILE209
B	SER255
B	CYS280
B	ASP281
B	TYR286
B	HOH2082
B	HOH2083
B	HOH2084
B	HOH2085

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE PLP C 320

Chain	Residue
C	LYS41
C	ASN71
C	SER172
C	GLY174
C	THR175
C	THR176
C	GLY177
C	THR178
C	GLY208
C	ILE209
C	SER255
C	CYS280
C	ASP281
C	TYR286
C	HOH2052
C	HOH2053
C	HOH2054

site_id	AC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE PLP D 320

Chain	Residue
D	LYS41
D	ASN71
D	SER172
D	GLY174
D	THR175
D	THR176
D	GLY177
D	THR178
D	GLY208
D	ILE209
D	SER255
D	CYS280
D	ASP281
D	TYR286
D	HOH2054
D	HOH2055
D	HOH2056
D	HOH2057

Functional Information from PROSITE/UniProt

site_id	PS00901
Number of Residues	19
Details	CYS_SYNTHASE Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. KlEgnn.PAgSVKdRaAlsM

Chain	Residue	Details
A	LYS30-MET48

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15952768","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine"}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1oas

Chain	Residue	Details
A	SER255
A	LYS41

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1oas

Chain	Residue	Details
B	SER255
B	LYS41

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1oas

Chain	Residue	Details
C	SER255
C	LYS41

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1oas

Chain	Residue	Details
D	SER255
D	LYS41

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1oas

Chain	Residue	Details
A	LYS41

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1oas

Chain	Residue	Details
B	LYS41

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1oas

Chain	Residue	Details
C	LYS41

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1oas

Chain	Residue	Details
D	LYS41

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)