2BHQ
Crystal Analysis of 1-Pyrroline-5-Carboxylate Dehydrogenase from Thermus with bound product glutamate.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003842 | molecular_function | L-glutamate gamma-semialdehyde dehydrogenase activity |
| A | 0004657 | molecular_function | proline dehydrogenase activity |
| A | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| A | 0010133 | biological_process | L-proline catabolic process to L-glutamate |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003842 | molecular_function | L-glutamate gamma-semialdehyde dehydrogenase activity |
| B | 0004657 | molecular_function | proline dehydrogenase activity |
| B | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| B | 0010133 | biological_process | L-proline catabolic process to L-glutamate |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A1524 |
| Chain | Residue |
| A | ARG462 |
| A | PHE464 |
| A | HIS465 |
| A | HOH2657 |
| A | HOH2658 |
| B | LYS510 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT B1519 |
| Chain | Residue |
| B | HIS465 |
| B | HOH2674 |
| B | HOH2675 |
| A | LYS510 |
| B | ARG462 |
| B | PHE464 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE GLU A1517 |
| Chain | Residue |
| A | ASN184 |
| A | PHE185 |
| A | ILE189 |
| A | GLU288 |
| A | LYS321 |
| A | CYS322 |
| A | SER323 |
| A | THR476 |
| A | GLY477 |
| A | ALA478 |
| A | PHE485 |
| A | HOH2267 |
| A | HOH2268 |
| A | HOH2333 |
| A | HOH2601 |
| A | HOH2646 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE GLU B1518 |
| Chain | Residue |
| B | ASN184 |
| B | PHE185 |
| B | ILE189 |
| B | GLU288 |
| B | LYS321 |
| B | CYS322 |
| B | SER323 |
| B | THR476 |
| B | GLY477 |
| B | ALA478 |
| B | PHE485 |
| B | HOH2298 |
| B | HOH2372 |
| B | HOH2627 |
| B | HOH2672 |
| B | HOH2673 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MRD A1518 |
| Chain | Residue |
| A | LEU275 |
| A | GLN279 |
| A | HOH2648 |
| A | HOH2649 |
| A | HOH2650 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MRD A1519 |
| Chain | Residue |
| A | ILE180 |
| A | GLU241 |
| A | GLY244 |
| A | ALA245 |
| A | HOH2358 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MRD A1522 |
| Chain | Residue |
| A | ARG151 |
| A | TYR171 |
| A | HOH2654 |
| A | HOH2655 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MRD B1517 |
| Chain | Residue |
| B | LEU275 |
| B | GLN279 |
| B | HOH2670 |
| B | HOH2671 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MRD B1521 |
| Chain | Residue |
| B | ILE180 |
| B | GLU241 |
| B | GLY244 |
| B | ALA245 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD A1520 |
| Chain | Residue |
| A | ARG36 |
| A | TRP46 |
| A | GLU221 |
| A | HOH2109 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE MPD A1521 |
| Chain | Residue |
| A | PHE6 |
| A | TYR144 |
| A | ARG147 |
| A | ALA148 |
| A | HOH2284 |
| A | HOH2651 |
| A | HOH2652 |
| A | HOH2653 |
| B | GLU158 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD A1523 |
| Chain | Residue |
| A | SER374 |
| A | ILE378 |
| A | HOH2488 |
| A | HOH2656 |
| site_id | BC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE MPD B1520 |
| Chain | Residue |
| A | GLU158 |
| B | PHE6 |
| B | TYR144 |
| B | ARG147 |
| B | ALA148 |
| B | HOH2311 |
| B | HOH2676 |
| B | HOH2677 |
| B | HOH2678 |
Functional Information from PROSITE/UniProt
| site_id | PS00070 |
| Number of Residues | 12 |
| Details | ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. YgFQGQKCSAAS |
| Chain | Residue | Details |
| A | TYR315-SER326 |
| site_id | PS00687 |
| Number of Residues | 8 |
| Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. VETGGKDA |
| Chain | Residue | Details |
| A | VAL287-ALA294 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| A | CYS322 | |
| A | ASN184 | |
| A | GLU288 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a4s |
| Chain | Residue | Details |
| B | CYS322 | |
| B | ASN184 | |
| B | GLU288 |
