2BHP
Crystal Analysis of 1-Pyrroline-5-Carboxylate Dehydrogenase from Thermus with bound NAD.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0003842 | molecular_function | 1-pyrroline-5-carboxylate dehydrogenase activity |
A | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
A | 0010133 | biological_process | proline catabolic process to glutamate |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
B | 0000166 | molecular_function | nucleotide binding |
B | 0003842 | molecular_function | 1-pyrroline-5-carboxylate dehydrogenase activity |
B | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
B | 0010133 | biological_process | proline catabolic process to glutamate |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE ACT A1518 |
Chain | Residue |
A | ALA245 |
A | GLU249 |
A | ILE268 |
A | ALA271 |
A | NAD1517 |
A | HOH2604 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE ACT A1519 |
Chain | Residue |
A | HOH2605 |
A | HOH2606 |
B | LYS510 |
A | ARG462 |
A | PHE464 |
A | HIS465 |
site_id | AC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE ACT A1520 |
Chain | Residue |
A | ARG20 |
A | ASN357 |
A | HOH2444 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA A1526 |
Chain | Residue |
A | SER55 |
A | LEU56 |
A | GLU123 |
A | ASP211 |
A | HOH2150 |
A | HOH2449 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE ACT B1520 |
Chain | Residue |
B | ALA245 |
B | GLU249 |
B | ILE268 |
B | ALA271 |
B | NAD1517 |
B | HOH2581 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE ACT B1521 |
Chain | Residue |
A | LYS510 |
B | ARG462 |
B | PHE464 |
B | HIS465 |
B | HOH2582 |
B | HOH2583 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA B1524 |
Chain | Residue |
B | SER55 |
B | LEU56 |
B | GLU123 |
B | ASP211 |
B | HOH2143 |
B | HOH2436 |
site_id | AC8 |
Number of Residues | 32 |
Details | BINDING SITE FOR RESIDUE NAD A1517 |
Chain | Residue |
A | ILE180 |
A | ALA181 |
A | PRO182 |
A | TRP183 |
A | ASN184 |
A | ILE189 |
A | LYS207 |
A | ALA209 |
A | GLU210 |
A | GLY240 |
A | GLY244 |
A | ALA245 |
A | PHE258 |
A | THR259 |
A | GLY260 |
A | SER261 |
A | VAL264 |
A | GLU288 |
A | THR289 |
A | GLY290 |
A | CYS322 |
A | GLU417 |
A | PHE419 |
A | LEU445 |
A | PHE485 |
A | ACT1518 |
A | HOH2323 |
A | HOH2345 |
A | HOH2600 |
A | HOH2601 |
A | HOH2602 |
A | HOH2603 |
site_id | AC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MRD A1521 |
Chain | Residue |
A | GLN279 |
A | HOH2607 |
A | HOH2608 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MRD A1523 |
Chain | Residue |
A | VAL312 |
A | ASP359 |
A | HOH2259 |
A | HOH2610 |
site_id | BC2 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE MRD A1527 |
Chain | Residue |
B | TYR171 |
site_id | BC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MRD A1528 |
Chain | Residue |
A | TYR144 |
A | ALA148 |
A | LEU500 |
A | HOH2281 |
A | HOH2612 |
A | HOH2613 |
B | GLU158 |
site_id | BC4 |
Number of Residues | 34 |
Details | BINDING SITE FOR RESIDUE NAD B1517 |
Chain | Residue |
B | THR259 |
B | GLY260 |
B | SER261 |
B | VAL264 |
B | GLU288 |
B | THR289 |
B | GLY290 |
B | CYS322 |
B | GLU417 |
B | PHE419 |
B | LEU445 |
B | PHE485 |
B | ACT1520 |
B | HOH2311 |
B | HOH2315 |
B | HOH2573 |
B | HOH2574 |
B | HOH2575 |
B | HOH2576 |
B | HOH2577 |
B | HOH2578 |
B | ILE180 |
B | ALA181 |
B | PRO182 |
B | TRP183 |
B | ASN184 |
B | ILE189 |
B | LYS207 |
B | ALA209 |
B | GLU210 |
B | GLY240 |
B | GLY244 |
B | ALA245 |
B | PHE258 |
site_id | BC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MRD B1523 |
Chain | Residue |
A | ARG28 |
A | TYR122 |
B | PRO353 |
B | GLU355 |
B | GLU356 |
B | HOH2584 |
B | HOH2585 |
site_id | BC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MRD B1527 |
Chain | Residue |
B | GLN279 |
B | HOH2586 |
B | HOH2587 |
site_id | BC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MPD A1522 |
Chain | Residue |
A | ARG36 |
A | TRP46 |
A | GLU221 |
A | HOH2111 |
site_id | BC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MPD A1524 |
Chain | Residue |
A | TYR375 |
A | ILE378 |
A | ARG412 |
A | HOH2457 |
A | HOH2461 |
site_id | BC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MPD A1525 |
Chain | Residue |
A | ARG151 |
A | TYR171 |
A | HOH2289 |
A | HOH2611 |
site_id | CC1 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE MPD B1518 |
Chain | Residue |
A | GLU158 |
A | HOH2303 |
B | PHE6 |
B | TYR144 |
B | ARG147 |
B | ALA148 |
B | HOH2262 |
B | HOH2579 |
B | HOH2580 |
Functional Information from PROSITE/UniProt
site_id | PS00070 |
Number of Residues | 12 |
Details | ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. YgFQGQKCSAAS |
Chain | Residue | Details |
A | TYR315-SER326 |
site_id | PS00687 |
Number of Residues | 8 |
Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. VETGGKDA |
Chain | Residue | Details |
A | VAL287-ALA294 |