Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004032 | molecular_function | aldose reductase (NADPH) activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE NDP A1321 |
| Chain | Residue |
| A | GLY30 |
| A | GLN188 |
| A | TYR214 |
| A | SER215 |
| A | PRO216 |
| A | LEU217 |
| A | GLY218 |
| A | SER219 |
| A | SER220 |
| A | ASN223 |
| A | ALA225 |
| A | THR31 |
| A | ILE257 |
| A | PRO258 |
| A | LYS259 |
| A | SER260 |
| A | SER261 |
| A | LYS262 |
| A | ARG265 |
| A | GLU268 |
| A | ASN269 |
| A | LEU295 |
| A | TRP32 |
| A | BCT1322 |
| A | HOH2020 |
| A | HOH2334 |
| A | HOH2335 |
| A | ASP55 |
| A | TYR60 |
| A | LYS88 |
| A | HIS121 |
| A | CYS166 |
| A | ASN167 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE BCT A1322 |
| Chain | Residue |
| A | TRP32 |
| A | TYR60 |
| A | HIS121 |
| A | TRP122 |
| A | NDP1321 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A1323 |
| Chain | Residue |
| A | VAL170 |
| A | ASN174 |
| A | LYS206 |
| A | HOH2337 |
| A | HOH2338 |
| A | HOH2339 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A1324 |
| Chain | Residue |
| A | HIS40 |
| A | LYS81 |
| A | TYR114 |
| A | LYS161 |
| A | ASP263 |
| A | HOH2340 |
| A | HOH2341 |
Functional Information from PROSITE/UniProt
| site_id | PS00062 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MenlvkdglVKDIGVCNY |
| Chain | Residue | Details |
| A | MET151-TYR168 | |
| site_id | PS00063 |
| Number of Residues | 16 |
| Details | ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. IPKSSKdeRIkENiQV |
| Chain | Residue | Details |
| A | ILE257-VAL272 | |
| site_id | PS00798 |
| Number of Residues | 18 |
| Details | ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHVDTAaeygvEkeVG |
| Chain | Residue | Details |
| A | GLY50-GLY67 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR60 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | SER215 | |
| A | HIS121 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Lowers pKa of active site Tyr => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS88 | |
