2BES

Structure of Mycobacterium tuberculosis Ribose-5-Phosphate Isomerase, RpiB, Rv2465c, in complex with 4-phospho-D-erythronohydroxamic acid.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004751	molecular_function	ribose-5-phosphate isomerase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005975	biological_process	carbohydrate metabolic process
A	0006098	biological_process	pentose-phosphate shunt
A	0009052	biological_process	pentose-phosphate shunt, non-oxidative branch
A	0016853	molecular_function	isomerase activity
A	0016861	molecular_function	intramolecular oxidoreductase activity, interconverting aldoses and ketoses
A	0019316	biological_process	D-allose catabolic process
B	0004751	molecular_function	ribose-5-phosphate isomerase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005975	biological_process	carbohydrate metabolic process
B	0006098	biological_process	pentose-phosphate shunt
B	0009052	biological_process	pentose-phosphate shunt, non-oxidative branch
B	0016853	molecular_function	isomerase activity
B	0016861	molecular_function	intramolecular oxidoreductase activity, interconverting aldoses and ketoses
B	0019316	biological_process	D-allose catabolic process
C	0004751	molecular_function	ribose-5-phosphate isomerase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005975	biological_process	carbohydrate metabolic process
C	0006098	biological_process	pentose-phosphate shunt
C	0009052	biological_process	pentose-phosphate shunt, non-oxidative branch
C	0016853	molecular_function	isomerase activity
C	0016861	molecular_function	intramolecular oxidoreductase activity, interconverting aldoses and ketoses
C	0019316	biological_process	D-allose catabolic process
D	0004751	molecular_function	ribose-5-phosphate isomerase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005975	biological_process	carbohydrate metabolic process
D	0006098	biological_process	pentose-phosphate shunt
D	0009052	biological_process	pentose-phosphate shunt, non-oxidative branch
D	0016853	molecular_function	isomerase activity
D	0016861	molecular_function	intramolecular oxidoreductase activity, interconverting aldoses and ketoses
D	0019316	biological_process	D-allose catabolic process
E	0004751	molecular_function	ribose-5-phosphate isomerase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005975	biological_process	carbohydrate metabolic process
E	0006098	biological_process	pentose-phosphate shunt
E	0009052	biological_process	pentose-phosphate shunt, non-oxidative branch
E	0016853	molecular_function	isomerase activity
E	0016861	molecular_function	intramolecular oxidoreductase activity, interconverting aldoses and ketoses
E	0019316	biological_process	D-allose catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE RES A 200

Chain	Residue
A	ASP11
A	HOH2063
A	HOH2064
A	HOH2065
A	HOH2066
B	HIS102
B	ASN103
B	ARG137
B	HIS138
B	ARG141
B	HOH2062
A	HIS12
A	ALA13
A	GLY70
A	SER71
A	ASN73
A	GLY74
A	GLU75
A	ARG113

---

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE RES B 200

Chain	Residue
A	HIS102
A	ASN103
A	ARG137
A	ARG141
A	HOH2050
B	ASP11
B	HIS12
B	ALA13
B	GLY70
B	SER71
B	ASN73
B	GLY74
B	GLU75
B	ARG113
B	HOH2019
B	HOH2079
B	HOH2080
B	HOH2081

---

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE RES C 200

Chain	Residue
C	ASP11
C	HIS12
C	GLY70
C	SER71
C	ASN73
C	GLY74
C	GLU75
C	ARG113
C	HOH2084
C	HOH2085
C	HOH2086
D	HIS102
D	ASN103
D	ARG137
D	HIS138
D	ARG141
D	HOH2072

---

site_id	AC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE RES D 200

Chain	Residue
C	HIS102
C	ASN103
C	ARG137
C	HIS138
C	ARG141
D	ASP11
D	HIS12
D	GLY70
D	SER71
D	ASN73
D	GLY74
D	GLU75
D	ARG113
D	HOH2020
D	HOH2094
D	HOH2095
D	HOH2096
D	HOH2097

---

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE RES E 200

Chain	Residue
E	ASP11
E	HIS12
E	GLY70
E	SER71
E	ASN73
E	GLY74
E	GLU75
E	HIS102
E	ASN103
E	ARG113
E	ARG137
E	ARG141
E	HOH2057
E	HOH2058
E	HOH2059
E	HOH2060

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"15590681","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18640127","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2BES","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"15590681","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18640127","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2BES","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14687575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15590681","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18640127","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1USL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BES","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15590681","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18640127","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BES","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15590681","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18640127","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BET","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14687575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18640127","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1USL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VVQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---