2BES
Structure of Mycobacterium tuberculosis Ribose-5-Phosphate Isomerase, RpiB, Rv2465c, in complex with 4-phospho-D-erythronohydroxamic acid.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004751 | molecular_function | ribose-5-phosphate isomerase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006098 | biological_process | pentose-phosphate shunt |
| A | 0009052 | biological_process | pentose-phosphate shunt, non-oxidative branch |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0016861 | molecular_function | intramolecular oxidoreductase activity, interconverting aldoses and ketoses |
| A | 0019316 | biological_process | D-allose catabolic process |
| B | 0004751 | molecular_function | ribose-5-phosphate isomerase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006098 | biological_process | pentose-phosphate shunt |
| B | 0009052 | biological_process | pentose-phosphate shunt, non-oxidative branch |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0016861 | molecular_function | intramolecular oxidoreductase activity, interconverting aldoses and ketoses |
| B | 0019316 | biological_process | D-allose catabolic process |
| C | 0004751 | molecular_function | ribose-5-phosphate isomerase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0006098 | biological_process | pentose-phosphate shunt |
| C | 0009052 | biological_process | pentose-phosphate shunt, non-oxidative branch |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0016861 | molecular_function | intramolecular oxidoreductase activity, interconverting aldoses and ketoses |
| C | 0019316 | biological_process | D-allose catabolic process |
| D | 0004751 | molecular_function | ribose-5-phosphate isomerase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0006098 | biological_process | pentose-phosphate shunt |
| D | 0009052 | biological_process | pentose-phosphate shunt, non-oxidative branch |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0016861 | molecular_function | intramolecular oxidoreductase activity, interconverting aldoses and ketoses |
| D | 0019316 | biological_process | D-allose catabolic process |
| E | 0004751 | molecular_function | ribose-5-phosphate isomerase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005576 | cellular_component | extracellular region |
| E | 0005975 | biological_process | carbohydrate metabolic process |
| E | 0006098 | biological_process | pentose-phosphate shunt |
| E | 0009052 | biological_process | pentose-phosphate shunt, non-oxidative branch |
| E | 0016853 | molecular_function | isomerase activity |
| E | 0016861 | molecular_function | intramolecular oxidoreductase activity, interconverting aldoses and ketoses |
| E | 0019316 | biological_process | D-allose catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE RES A 200 |
| Chain | Residue |
| A | ASP11 |
| A | HOH2063 |
| A | HOH2064 |
| A | HOH2065 |
| A | HOH2066 |
| B | HIS102 |
| B | ASN103 |
| B | ARG137 |
| B | HIS138 |
| B | ARG141 |
| B | HOH2062 |
| A | HIS12 |
| A | ALA13 |
| A | GLY70 |
| A | SER71 |
| A | ASN73 |
| A | GLY74 |
| A | GLU75 |
| A | ARG113 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE RES B 200 |
| Chain | Residue |
| A | HIS102 |
| A | ASN103 |
| A | ARG137 |
| A | ARG141 |
| A | HOH2050 |
| B | ASP11 |
| B | HIS12 |
| B | ALA13 |
| B | GLY70 |
| B | SER71 |
| B | ASN73 |
| B | GLY74 |
| B | GLU75 |
| B | ARG113 |
| B | HOH2019 |
| B | HOH2079 |
| B | HOH2080 |
| B | HOH2081 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE RES C 200 |
| Chain | Residue |
| C | ASP11 |
| C | HIS12 |
| C | GLY70 |
| C | SER71 |
| C | ASN73 |
| C | GLY74 |
| C | GLU75 |
| C | ARG113 |
| C | HOH2084 |
| C | HOH2085 |
| C | HOH2086 |
| D | HIS102 |
| D | ASN103 |
| D | ARG137 |
| D | HIS138 |
| D | ARG141 |
| D | HOH2072 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE RES D 200 |
| Chain | Residue |
| C | HIS102 |
| C | ASN103 |
| C | ARG137 |
| C | HIS138 |
| C | ARG141 |
| D | ASP11 |
| D | HIS12 |
| D | GLY70 |
| D | SER71 |
| D | ASN73 |
| D | GLY74 |
| D | GLU75 |
| D | ARG113 |
| D | HOH2020 |
| D | HOH2094 |
| D | HOH2095 |
| D | HOH2096 |
| D | HOH2097 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE RES E 200 |
| Chain | Residue |
| E | ASP11 |
| E | HIS12 |
| E | GLY70 |
| E | SER71 |
| E | ASN73 |
| E | GLY74 |
| E | GLU75 |
| E | HIS102 |
| E | ASN103 |
| E | ARG113 |
| E | ARG137 |
| E | ARG141 |
| E | HOH2057 |
| E | HOH2058 |
| E | HOH2059 |
| E | HOH2060 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:15590681, ECO:0000305|PubMed:18640127, ECO:0007744|PDB:2BES, ECO:0007744|PDB:2BET, ECO:0007744|PDB:2VVO, ECO:0007744|PDB:2VVP, ECO:0007744|PDB:2VVQ |
| Chain | Residue | Details |
| A | ALA78 | |
| B | ALA78 | |
| C | ALA78 | |
| D | ALA78 | |
| E | ALA78 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:15590681, ECO:0000305|PubMed:18640127, ECO:0007744|PDB:2BES, ECO:0007744|PDB:2BET, ECO:0007744|PDB:2VVO, ECO:0007744|PDB:2VVP, ECO:0007744|PDB:2VVQ |
| Chain | Residue | Details |
| A | ALA105 | |
| B | ALA105 | |
| C | ALA105 | |
| D | ALA105 | |
| E | ALA105 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 15 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14687575, ECO:0000269|PubMed:15590681, ECO:0000269|PubMed:18640127, ECO:0007744|PDB:1USL, ECO:0007744|PDB:2BES, ECO:0007744|PDB:2BET, ECO:0007744|PDB:2VVO, ECO:0007744|PDB:2VVP, ECO:0007744|PDB:2VVQ |
| Chain | Residue | Details |
| A | GLY14 | |
| D | GLY14 | |
| D | THR116 | |
| D | ARG140 | |
| E | GLY14 | |
| E | THR116 | |
| E | ARG140 | |
| A | THR116 | |
| A | ARG140 | |
| B | GLY14 | |
| B | THR116 | |
| B | ARG140 | |
| C | GLY14 | |
| C | THR116 | |
| C | ARG140 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15590681, ECO:0000269|PubMed:18640127, ECO:0007744|PDB:2BES, ECO:0007744|PDB:2BET, ECO:0007744|PDB:2VVO, ECO:0007744|PDB:2VVP, ECO:0007744|PDB:2VVQ |
| Chain | Residue | Details |
| A | ASN73 | |
| B | ASN73 | |
| C | ASN73 | |
| D | ASN73 | |
| E | ASN73 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15590681, ECO:0000269|PubMed:18640127, ECO:0007744|PDB:2BET, ECO:0007744|PDB:2VVO, ECO:0007744|PDB:2VVP |
| Chain | Residue | Details |
| A | GLN106 | |
| B | GLN106 | |
| C | GLN106 | |
| D | GLN106 | |
| E | GLN106 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14687575, ECO:0000269|PubMed:18640127, ECO:0007744|PDB:1USL, ECO:0007744|PDB:2VVO, ECO:0007744|PDB:2VVP, ECO:0007744|PDB:2VVQ |
| Chain | Residue | Details |
| A | ILE144 | |
| B | ILE144 | |
| C | ILE144 | |
| D | ILE144 | |
| E | ILE144 |
