Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0007596 | biological_process | blood coagulation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 402 |
| Chain | Residue |
| A | ARG263 |
| A | LYS266 |
| A | HOH435 |
| A | HOH436 |
| A | HOH442 |
| A | HOH454 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE UNB A 401 |
| Chain | Residue |
| A | GLU130 |
| A | LEU132 |
| A | ILE209 |
| A | ASP229 |
| A | ALA230 |
| A | CYS231 |
| A | SER235 |
| A | SER256 |
| A | TRP257 |
| A | GLY258 |
| A | GLY260 |
| A | CYS261 |
| A | GLY268 |
| A | HOH734 |
| A | HOH735 |
| A | HOH736 |
| A | HOH742 |
| A | HIS79 |
| A | TYR83 |
| A | TRP86 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR CHAIN B OF HIRUDIN IIIB' |
| Chain | Residue |
| A | PHE55 |
| A | GLN60 |
| A | LEU62 |
| A | LEU96 |
| A | ARG98 |
| A | ARG104 |
| A | THR105 |
| A | ARG106 |
| A | TYR107 |
| A | GLU112 |
| A | LYS113 |
| A | ILE114 |
| A | HOH441 |
| A | HOH465 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| A | LEU75-CYS80 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV |
| Chain | Residue | Details |
| A | ASP229-VAL240 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| B | TYS363 | |
| A | ASP135 | |
| A | SER235 | |
| Chain | Residue | Details |
| A | ARG36 | |
| Chain | Residue | Details |
| A | ASN89 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP135 | |
| A | HIS79 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | GLY236 | |
| A | SER235 | |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | GLY233 | |
| A | SER235 | |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP135 | |
| A | HIS79 | |
| A | SER235 | |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | GLY236 | |
| A | ASP135 | |
| A | HIS79 | |
| A | SER235 | |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP135 | |
| A | HIS79 | |
| A | GLY233 | |
| A | SER235 | |
