2BCR

DNA polymerase lambda in complex with a DNA duplex containing an unpaired Damp

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034061	molecular_function	DNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 600

Chain	Residue
A	ASP427
A	ASP429
A	PPV638
A	HOH813
P	DG7

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 602

Chain	Residue
T	HOH54
T	HOH98
A	SER463
A	HOH945
A	HOH946
T	HOH40

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 603

Chain	Residue
A	SER339
A	ILE341
A	ALA344
P	DA5
P	HOH45
P	HOH251

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 604

Chain	Residue
A	CYS300
A	ILE302
A	ILE305
A	HOH1105
D	DC3
D	HOH406

---

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PPV A 638

Chain	Residue
A	ARG386
A	GLY416
A	SER417
A	ARG420
A	GLY426
A	MG600
A	HOH839
A	HOH846
A	HOH967
A	HOH1041
P	DG7
P	HOH96

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 801

Chain	Residue
A	ARG452
A	LEU457
A	ASP460
A	HOH1135

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 802

Chain	Residue
A	GLN471
A	VAL494
A	HIS530
A	HOH856
A	HOH950
A	HOH981
T	DA9

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO P 803

Chain	Residue
A	THR348
A	MET351
A	GLU385
A	ARG485
P	DG3

---

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 804

Chain	Residue
A	ARG419
A	THR555
A	GLU556
A	LYS557
A	TYR567
A	HOH835
A	HOH1000
A	HOH1068

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 805

Chain	Residue
A	LYS347
A	GLY481
A	PRO482
A	GLY483
A	ARG484
A	HOH896

---

Functional Information from PROSITE/UniProt

site_id	PS00522
Number of Residues	20
Details	DNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP

Chain	Residue	Details
A	GLY416-PRO435

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	56
Details	Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"14992725","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Region: {"description":"Involved in primer binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Schiff-base intermediate with DNA","evidences":[{"source":"PubMed","id":"11457865","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17475573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PFQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17475573","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2PFO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PFQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1jms

Chain	Residue	Details
A	ASP490

---