2BCP
Structural Analysis of Streptococcus pyogenes NADH oxidase: C44S Nox with Azide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0055085 | biological_process | transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE AZI A 668 |
| Chain | Residue |
| A | HIS11 |
| A | LEU42 |
| A | GLY43 |
| A | SER44 |
| A | FAD601 |
| B | PHE436 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE AZI B 669 |
| Chain | Residue |
| B | SER44 |
| B | FAD602 |
| A | PHE436 |
| B | HIS11 |
| B | GLY43 |
| site_id | AC3 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE FAD A 601 |
| Chain | Residue |
| A | VAL7 |
| A | GLY8 |
| A | ASN10 |
| A | HIS11 |
| A | ALA12 |
| A | ASP34 |
| A | GLN35 |
| A | ASN36 |
| A | GLY43 |
| A | SER44 |
| A | VAL81 |
| A | ALA110 |
| A | THR111 |
| A | GLY112 |
| A | SER113 |
| A | LYS143 |
| A | TYR170 |
| A | PHE255 |
| A | LEU261 |
| A | GLY291 |
| A | ASP292 |
| A | ALA308 |
| A | LEU309 |
| A | ALA310 |
| A | SER311 |
| A | AZI668 |
| A | HOH675 |
| A | HOH681 |
| A | HOH689 |
| A | HOH691 |
| A | HOH693 |
| A | HOH802 |
| B | PHE436 |
| B | LEU437 |
| site_id | AC4 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE FAD B 602 |
| Chain | Residue |
| A | PHE436 |
| A | HOH702 |
| B | GLY8 |
| B | ASN10 |
| B | HIS11 |
| B | ALA12 |
| B | ASP34 |
| B | GLN35 |
| B | ASN36 |
| B | GLY43 |
| B | SER44 |
| B | PRO80 |
| B | VAL81 |
| B | ALA110 |
| B | THR111 |
| B | GLY112 |
| B | SER113 |
| B | VAL142 |
| B | LYS143 |
| B | TYR170 |
| B | PHE255 |
| B | GLY291 |
| B | ASP292 |
| B | ALA308 |
| B | LEU309 |
| B | ALA310 |
| B | SER311 |
| B | AZI669 |
| B | HOH674 |
| B | HOH686 |
| B | HOH700 |
| B | HOH718 |
| B | HOH728 |
| B | HOH920 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P37062 |
| Chain | Residue | Details |
| A | HIS11 | |
| B | HIS11 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Redox-active => ECO:0000269|PubMed:26506002, ECO:0007744|PDB:2BC0 |
| Chain | Residue | Details |
| A | SER44 | |
| B | SER44 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 22 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26506002, ECO:0007744|PDB:2BC0, ECO:0007744|PDB:2BC1, ECO:0007744|PDB:2BCP |
| Chain | Residue | Details |
| A | ASP34 | |
| A | GLN35 | |
| A | VAL81 | |
| A | SER113 | |
| A | LYS143 | |
| A | LEU309 | |
| A | SER311 | |
| B | ASN10 | |
| B | ALA12 | |
| B | ASP34 | |
| B | GLN35 | |
| B | VAL81 | |
| B | SER113 | |
| B | LYS143 | |
| B | LEU309 | |
| B | SER311 | |
| A | ASP292 | |
| A | ALA310 | |
| B | ASP292 | |
| B | ALA310 | |
| A | ASN10 | |
| A | ALA12 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26506002, ECO:0007744|PDB:2BC0 |
| Chain | Residue | Details |
| B | SER44 | |
| A | SER44 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26506002, ECO:0007744|PDB:2BC0, ECO:0007744|PDB:2BCP |
| Chain | Residue | Details |
| B | ALA110 | |
| A | ALA110 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26506002, ECO:0007744|PDB:2BC1, ECO:0007744|PDB:2BCP |
| Chain | Residue | Details |
| A | TYR170 | |
| B | TYR170 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P37062 |
| Chain | Residue | Details |
| A | ILE171 | |
| A | ASP190 | |
| A | TYR199 | |
| A | GLY254 | |
| A | ALA308 | |
| A | GLY339 | |
| B | ILE171 | |
| B | ASP190 | |
| B | TYR199 | |
| B | GLY254 | |
| B | ALA308 | |
| B | GLY339 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26506002, ECO:0007744|PDB:2BC0, ECO:0007744|PDB:2BC1 |
| Chain | Residue | Details |
| A | PHE436 | |
| B | PHE436 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Cysteine sulfinic acid (-SO2H) => ECO:0000269|PubMed:26506002, ECO:0007744|PDB:2BC0 |
| Chain | Residue | Details |
| A | SER44 | |
| B | SER44 |
