2BC0
Structural Analysis of Streptococcus pyogenes NADH oxidase: Wild-type Nox
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 1902600 | biological_process | proton transmembrane transport |
| B | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 1902600 | biological_process | proton transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE FAD A 601 |
| Chain | Residue |
| A | VAL7 |
| A | CSD44 |
| A | MET46 |
| A | PRO80 |
| A | VAL81 |
| A | ALA110 |
| A | THR111 |
| A | GLY112 |
| A | SER113 |
| A | LYS143 |
| A | TYR170 |
| A | GLY8 |
| A | ILE171 |
| A | PHE255 |
| A | GLY291 |
| A | ASP292 |
| A | ALA308 |
| A | LEU309 |
| A | ALA310 |
| A | SER311 |
| A | HOH607 |
| A | HOH608 |
| A | ASN10 |
| A | HOH619 |
| A | HOH709 |
| A | HOH732 |
| A | HOH759 |
| A | HOH857 |
| B | PHE436 |
| B | LEU437 |
| A | HIS11 |
| A | ALA12 |
| A | PHE33 |
| A | ASP34 |
| A | GLN35 |
| A | ASN36 |
| site_id | AC2 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE FAD B 602 |
| Chain | Residue |
| A | PHE436 |
| A | LEU437 |
| B | VAL7 |
| B | GLY8 |
| B | ASN10 |
| B | HIS11 |
| B | ALA12 |
| B | ASP34 |
| B | GLN35 |
| B | ASN36 |
| B | CSD44 |
| B | PRO80 |
| B | VAL81 |
| B | ALA110 |
| B | THR111 |
| B | GLY112 |
| B | SER113 |
| B | VAL142 |
| B | LYS143 |
| B | TYR170 |
| B | ILE171 |
| B | PHE255 |
| B | GLY291 |
| B | ASP292 |
| B | ALA308 |
| B | LEU309 |
| B | ALA310 |
| B | SER311 |
| B | HOH614 |
| B | HOH619 |
| B | HOH629 |
| B | HOH630 |
| B | HOH635 |
| B | HOH638 |
| B | HOH746 |
| B | HOH885 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P37062","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Redox-active","evidences":[{"source":"PubMed","id":"26506002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BC0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 22 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26506002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BC1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BCP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26506002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BC0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26506002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BCP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26506002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BC1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BCP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P37062","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26506002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BC0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BC1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Cysteine sulfinic acid (-SO2H)","evidences":[{"source":"PubMed","id":"26506002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BC0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| A | HIS439 | |
| A | TYR444 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| B | HIS439 | |
| B | TYR444 |
