2B9E

Human NSUN5 protein

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001510	biological_process	RNA methylation
A	0008168	molecular_function	methyltransferase activity
A	0008173	molecular_function	RNA methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE SAM A 1201

Chain	Residue
A	ALA233
A	LEU259
A	ASP260
A	ARG263
A	GLU284
A	ASP285
A	PHE286
A	ASP305
A	SER307
A	PHE337
A	HOH1210
A	CYS234
A	HOH1361
A	HOH1376
A	HOH1413
A	HOH1442
A	ALA235
A	ALA236
A	PRO237
A	GLY238
A	ASN239
A	LYS240
A	ASP258

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU01023, ECO:0000305|PubMed:31722427

Chain	Residue	Details
A	CYS359

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
A	CYS234

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site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01023, ECO:0000269|Ref.14

Chain	Residue	Details
A	ASP258
A	ARG263
A	ASP305

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER167

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