2B96

Third Calcium ion found in an inhibitor bound phospholipase A2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002227	biological_process	innate immune response in mucosa
A	0004623	molecular_function	phospholipase A2 activity
A	0005102	molecular_function	signaling receptor binding
A	0005509	molecular_function	calcium ion binding
A	0005543	molecular_function	phospholipid binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006629	biological_process	lipid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0006644	biological_process	phospholipid metabolic process
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009986	cellular_component	cell surface
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0019731	biological_process	antibacterial humoral response
A	0032052	molecular_function	bile acid binding
A	0046470	biological_process	phosphatidylcholine metabolic process
A	0046471	biological_process	phosphatidylglycerol metabolic process
A	0046872	molecular_function	metal ion binding
A	0047498	molecular_function	calcium-dependent phospholipase A2 activity
A	0048146	biological_process	positive regulation of fibroblast proliferation
A	0050482	biological_process	arachidonate secretion
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
A	1904635	biological_process	positive regulation of podocyte apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 124

Chain	Residue
A	TYR28
A	GLY30
A	GLY32
A	ASP49
A	HOH203
A	ANN501
A	TRS604

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 125

Chain	Residue
A	GLU92
A	HOH226
A	HOH233
A	HOH317
A	ASN71
A	ASN72

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 126

Chain	Residue
A	ASN112
A	CYS123
A	HOH223
A	HOH248
A	HOH249
A	TRS601

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 127

Chain	Residue
A	LYS12
A	ILE82
A	ARG100

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TRS A 601

Chain	Residue
A	VAL63
A	ASN112
A	LYS120
A	MET121
A	CYS123
A	CA126
A	HOH223
A	HOH249
A	HOH284

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE TRS A 602

Chain	Residue
A	GLY33
A	MET56
A	CYS61
A	LYS62
A	LEU64
A	ASP66
A	HOH229

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE TRS A 603

Chain	Residue
A	PHE106
A	VAL109
A	HOH210
A	HOH287

---

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TRS A 604

Chain	Residue
A	ASN24
A	TYR25
A	GLY26
A	CYS27
A	TYR28
A	CYS29
A	GLY30
A	LEU31
A	GLY32
A	LYS120
A	CA124

---

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ANN A 501

Chain	Residue
A	PHE5
A	LEU19
A	TYR28
A	GLY30
A	ASP49
A	TYR69
A	CA124
A	HOH204

---

Functional Information from PROSITE/UniProt

site_id	PS00118
Number of Residues	8
Details	PA2_HIS Phospholipase A2 histidine active site. CCQtHDnC

Chain	Residue	Details
A	CYS44-CYS51

---

site_id	PS00119
Number of Residues	11
Details	PA2_ASP Phospholipase A2 aspartic acid active site. ICNCDRNAaIC

Chain	Residue	Details
A	ILE95-CYS105

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"7464926","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10089353","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7265241","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9115986","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BP2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MKS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1n29

Chain	Residue	Details
A	HIS48
A	GLY30
A	ASP99

---