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2B8U

Crystal structure of wildtype human Interleukin-4

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0005125molecular_functioncytokine activity
A0005126molecular_functioncytokine receptor binding
A0005136molecular_functioninterleukin-4 receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006955biological_processimmune response
A0008083molecular_functiongrowth factor activity
A0008203biological_processcholesterol metabolic process
A0008284biological_processpositive regulation of cell population proliferation
A0010628biological_processpositive regulation of gene expression
A0010633biological_processnegative regulation of epithelial cell migration
A0016239biological_processpositive regulation of macroautophagy
A0030183biological_processB cell differentiation
A0030335biological_processpositive regulation of cell migration
A0030890biological_processpositive regulation of B cell proliferation
A0032720biological_processnegative regulation of tumor necrosis factor production
A0032733biological_processpositive regulation of interleukin-10 production
A0032736biological_processpositive regulation of interleukin-13 production
A0035771biological_processinterleukin-4-mediated signaling pathway
A0042092biological_processtype 2 immune response
A0042102biological_processpositive regulation of T cell proliferation
A0042110biological_processT cell activation
A0042113biological_processB cell activation
A0042116biological_processmacrophage activation
A0042325biological_processregulation of phosphorylation
A0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
A0042976biological_processactivation of Janus kinase activity
A0043011biological_processmyeloid dendritic cell differentiation
A0043066biological_processnegative regulation of apoptotic process
A0045191biological_processregulation of isotype switching
A0045348biological_processpositive regulation of MHC class II biosynthetic process
A0045582biological_processpositive regulation of T cell differentiation
A0045671biological_processnegative regulation of osteoclast differentiation
A0045892biological_processnegative regulation of DNA-templated transcription
A0045893biological_processpositive regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048260biological_processpositive regulation of receptor-mediated endocytosis
A0048295biological_processpositive regulation of isotype switching to IgE isotypes
A0048304biological_processpositive regulation of isotype switching to IgG isotypes
A0050728biological_processnegative regulation of inflammatory response
A0050776biological_processregulation of immune response
A0097028biological_processdendritic cell differentiation
A0120162biological_processpositive regulation of cold-induced thermogenesis
A0150076biological_processneuroinflammatory response
A0150079biological_processnegative regulation of neuroinflammatory response
A1900223biological_processpositive regulation of amyloid-beta clearance
A1901857biological_processpositive regulation of cellular respiration
A1903660biological_processnegative regulation of complement-dependent cytotoxicity
A1903845biological_processnegative regulation of cellular response to transforming growth factor beta stimulus
A2000352biological_processnegative regulation of endothelial cell apoptotic process
A2000553biological_processpositive regulation of T-helper 2 cell cytokine production
A2001171biological_processpositive regulation of ATP biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 1001
ChainResidue
AARG53
ATYR56
ALYS61
AASP62
ATHR63
AHOH1066
AHOH1112

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 1002
ChainResidue
AHOH1007
AHOH1042
AHIS59
AARG64

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 1003
ChainResidue
AARG85
AARG88
AHOH1121

Functional Information from PROSITE/UniProt
site_idPS00838
Number of Residues26
DetailsINTERLEUKIN_4_13 Interleukins -4 and -13 signature. LqEIIktlnsLTeqktl..CteltVtDI
ChainResidueDetails
ALEU7-ILE32

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:1993171
ChainResidueDetails
AASN38

219869

PDB entries from 2024-05-15

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