2B8T
Crystal structure of Thymidine Kinase from U.urealyticum in complex with thymidine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004797 | molecular_function | thymidine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009157 | biological_process | deoxyribonucleoside monophosphate biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0046104 | biological_process | thymidine metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0071897 | biological_process | DNA biosynthetic process |
| B | 0004797 | molecular_function | thymidine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006259 | biological_process | DNA metabolic process |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0009157 | biological_process | deoxyribonucleoside monophosphate biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0046104 | biological_process | thymidine metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0071897 | biological_process | DNA biosynthetic process |
| C | 0004797 | molecular_function | thymidine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006259 | biological_process | DNA metabolic process |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0009157 | biological_process | deoxyribonucleoside monophosphate biosynthetic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0046104 | biological_process | thymidine metabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0071897 | biological_process | DNA biosynthetic process |
| D | 0004797 | molecular_function | thymidine kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006259 | biological_process | DNA metabolic process |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0009157 | biological_process | deoxyribonucleoside monophosphate biosynthetic process |
| D | 0016301 | molecular_function | kinase activity |
| D | 0046104 | biological_process | thymidine metabolic process |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0071897 | biological_process | DNA biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1218 |
| Chain | Residue |
| A | CYS153 |
| A | CYS156 |
| A | CYS191 |
| A | HIS194 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 2218 |
| Chain | Residue |
| B | CYS153 |
| B | CYS156 |
| B | CYS191 |
| B | HIS194 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 3218 |
| Chain | Residue |
| C | CYS156 |
| C | CYS191 |
| C | HIS194 |
| C | CYS153 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 4218 |
| Chain | Residue |
| D | CYS153 |
| D | CYS156 |
| D | CYS191 |
| D | HIS194 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE THM A 4970 |
| Chain | Residue |
| A | GLU97 |
| A | PHE100 |
| A | LEU124 |
| A | ASN127 |
| A | PHE128 |
| A | PHE133 |
| A | SER163 |
| A | ARG165 |
| A | ILE178 |
| A | VAL179 |
| A | LYS180 |
| A | ILE181 |
| A | GLY182 |
| A | TYR187 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE THM B 5970 |
| Chain | Residue |
| B | GLU97 |
| B | PHE100 |
| B | LEU124 |
| B | ASN127 |
| B | PHE128 |
| B | PHE133 |
| B | SER163 |
| B | ARG165 |
| B | ILE178 |
| B | VAL179 |
| B | LYS180 |
| B | ILE181 |
| B | GLY182 |
| B | TYR187 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE THM C 6970 |
| Chain | Residue |
| C | GLU97 |
| C | PHE100 |
| C | LEU124 |
| C | ASN127 |
| C | PHE128 |
| C | PHE133 |
| C | SER163 |
| C | ARG165 |
| C | ILE178 |
| C | VAL179 |
| C | LYS180 |
| C | ILE181 |
| C | GLY182 |
| C | TYR187 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE THM D 7970 |
| Chain | Residue |
| D | GLU97 |
| D | PHE100 |
| D | LEU124 |
| D | ASN127 |
| D | PHE128 |
| D | PHE133 |
| D | SER163 |
| D | ARG165 |
| D | ILE178 |
| D | VAL179 |
| D | LYS180 |
| D | GLY182 |
| D | TYR187 |
| D | HOH8015 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE TRS D 5006 |
| Chain | Residue |
| D | PRO20 |
| D | MET21 |
| D | PHE22 |
| D | ALA23 |
| D | GLY24 |
| D | LYS25 |
| D | THR26 |
| D | ARG61 |
| D | HOH7980 |
| D | HOH8015 |
| D | HOH8023 |
Functional Information from PROSITE/UniProt
| site_id | PS00603 |
| Number of Residues | 14 |
| Details | TK_CELLULAR_TYPE Thymidine kinase cellular-type signature. GcqEfYsAvCRhHH |
| Chain | Residue | Details |
| A | GLY182-HIS195 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00124 |
| Chain | Residue | Details |
| A | GLU97 | |
| B | GLU97 | |
| C | GLU97 | |
| D | GLU97 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00124 |
| Chain | Residue | Details |
| A | GLY19 | |
| A | ASP96 | |
| B | GLY19 | |
| B | ASP96 | |
| C | GLY19 | |
| C | ASP96 | |
| D | GLY19 | |
| D | ASP96 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 28 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | PHE128 | |
| B | CYS156 | |
| B | ILE178 | |
| B | TYR187 | |
| B | CYS191 | |
| B | HIS194 | |
| C | PHE128 | |
| C | CYS153 | |
| C | CYS156 | |
| C | ILE178 | |
| C | TYR187 | |
| A | CYS153 | |
| C | CYS191 | |
| C | HIS194 | |
| D | PHE128 | |
| D | CYS153 | |
| D | CYS156 | |
| D | ILE178 | |
| D | TYR187 | |
| D | CYS191 | |
| D | HIS194 | |
| A | CYS156 | |
| A | ILE178 | |
| A | TYR187 | |
| A | CYS191 | |
| A | HIS194 | |
| B | PHE128 | |
| B | CYS153 |
