2B8T

Crystal structure of Thymidine Kinase from U.urealyticum in complex with thymidine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004797	molecular_function	thymidine kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006259	biological_process	DNA metabolic process
A	0008270	molecular_function	zinc ion binding
A	0009157	biological_process	deoxyribonucleoside monophosphate biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0046104	biological_process	thymidine metabolic process
A	0046872	molecular_function	metal ion binding
A	0071897	biological_process	DNA biosynthetic process
B	0000166	molecular_function	nucleotide binding
B	0004797	molecular_function	thymidine kinase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006259	biological_process	DNA metabolic process
B	0008270	molecular_function	zinc ion binding
B	0009157	biological_process	deoxyribonucleoside monophosphate biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0046104	biological_process	thymidine metabolic process
B	0046872	molecular_function	metal ion binding
B	0071897	biological_process	DNA biosynthetic process
C	0000166	molecular_function	nucleotide binding
C	0004797	molecular_function	thymidine kinase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006259	biological_process	DNA metabolic process
C	0008270	molecular_function	zinc ion binding
C	0009157	biological_process	deoxyribonucleoside monophosphate biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0046104	biological_process	thymidine metabolic process
C	0046872	molecular_function	metal ion binding
C	0071897	biological_process	DNA biosynthetic process
D	0000166	molecular_function	nucleotide binding
D	0004797	molecular_function	thymidine kinase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006259	biological_process	DNA metabolic process
D	0008270	molecular_function	zinc ion binding
D	0009157	biological_process	deoxyribonucleoside monophosphate biosynthetic process
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0046104	biological_process	thymidine metabolic process
D	0046872	molecular_function	metal ion binding
D	0071897	biological_process	DNA biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1218

Chain	Residue
A	CYS153
A	CYS156
A	CYS191
A	HIS194

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 2218

Chain	Residue
B	CYS153
B	CYS156
B	CYS191
B	HIS194

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 3218

Chain	Residue
C	CYS156
C	CYS191
C	HIS194
C	CYS153

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 4218

Chain	Residue
D	CYS153
D	CYS156
D	CYS191
D	HIS194

---

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE THM A 4970

Chain	Residue
A	GLU97
A	PHE100
A	LEU124
A	ASN127
A	PHE128
A	PHE133
A	SER163
A	ARG165
A	ILE178
A	VAL179
A	LYS180
A	ILE181
A	GLY182
A	TYR187

---

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE THM B 5970

Chain	Residue
B	GLU97
B	PHE100
B	LEU124
B	ASN127
B	PHE128
B	PHE133
B	SER163
B	ARG165
B	ILE178
B	VAL179
B	LYS180
B	ILE181
B	GLY182
B	TYR187

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE THM C 6970

Chain	Residue
C	GLU97
C	PHE100
C	LEU124
C	ASN127
C	PHE128
C	PHE133
C	SER163
C	ARG165
C	ILE178
C	VAL179
C	LYS180
C	ILE181
C	GLY182
C	TYR187

---

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE THM D 7970

Chain	Residue
D	GLU97
D	PHE100
D	LEU124
D	ASN127
D	PHE128
D	PHE133
D	SER163
D	ARG165
D	ILE178
D	VAL179
D	LYS180
D	GLY182
D	TYR187
D	HOH8015

---

site_id	AC9
Number of Residues	11
Details	BINDING SITE FOR RESIDUE TRS D 5006

Chain	Residue
D	PRO20
D	MET21
D	PHE22
D	ALA23
D	GLY24
D	LYS25
D	THR26
D	ARG61
D	HOH7980
D	HOH8015
D	HOH8023

---

Functional Information from PROSITE/UniProt

site_id	PS00603
Number of Residues	14
Details	TK_CELLULAR_TYPE Thymidine kinase cellular-type signature. GcqEfYsAvCRhHH

Chain	Residue	Details
A	GLY182-HIS195

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	40
Details	Binding site: {}

Chain

Residue

Details

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