2B3J

Crystal Structure of Staphylococcus aureus tRNA Adenosine Deaminase, TadA, in Complex with RNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002100	biological_process	tRNA wobble adenosine to inosine editing
A	0003824	molecular_function	catalytic activity
A	0004131	molecular_function	cytosine deaminase activity
A	0005737	cellular_component	cytoplasm
A	0008033	biological_process	tRNA processing
A	0008251	molecular_function	tRNA-specific adenosine deaminase activity
A	0008270	molecular_function	zinc ion binding
A	0008655	biological_process	pyrimidine-containing compound salvage
A	0016787	molecular_function	hydrolase activity
A	0019858	biological_process	cytosine metabolic process
A	0046087	biological_process	cytidine metabolic process
A	0046872	molecular_function	metal ion binding
A	0052717	molecular_function	tRNA-specific adenosine-34 deaminase activity
B	0002100	biological_process	tRNA wobble adenosine to inosine editing
B	0003824	molecular_function	catalytic activity
B	0004131	molecular_function	cytosine deaminase activity
B	0005737	cellular_component	cytoplasm
B	0008033	biological_process	tRNA processing
B	0008251	molecular_function	tRNA-specific adenosine deaminase activity
B	0008270	molecular_function	zinc ion binding
B	0008655	biological_process	pyrimidine-containing compound salvage
B	0016787	molecular_function	hydrolase activity
B	0019858	biological_process	cytosine metabolic process
B	0046087	biological_process	cytidine metabolic process
B	0046872	molecular_function	metal ion binding
B	0052717	molecular_function	tRNA-specific adenosine-34 deaminase activity
C	0002100	biological_process	tRNA wobble adenosine to inosine editing
C	0003824	molecular_function	catalytic activity
C	0004131	molecular_function	cytosine deaminase activity
C	0005737	cellular_component	cytoplasm
C	0008033	biological_process	tRNA processing
C	0008251	molecular_function	tRNA-specific adenosine deaminase activity
C	0008270	molecular_function	zinc ion binding
C	0008655	biological_process	pyrimidine-containing compound salvage
C	0016787	molecular_function	hydrolase activity
C	0019858	biological_process	cytosine metabolic process
C	0046087	biological_process	cytidine metabolic process
C	0046872	molecular_function	metal ion binding
C	0052717	molecular_function	tRNA-specific adenosine-34 deaminase activity
D	0002100	biological_process	tRNA wobble adenosine to inosine editing
D	0003824	molecular_function	catalytic activity
D	0004131	molecular_function	cytosine deaminase activity
D	0005737	cellular_component	cytoplasm
D	0008033	biological_process	tRNA processing
D	0008251	molecular_function	tRNA-specific adenosine deaminase activity
D	0008270	molecular_function	zinc ion binding
D	0008655	biological_process	pyrimidine-containing compound salvage
D	0016787	molecular_function	hydrolase activity
D	0019858	biological_process	cytosine metabolic process
D	0046087	biological_process	cytidine metabolic process
D	0046872	molecular_function	metal ion binding
D	0052717	molecular_function	tRNA-specific adenosine-34 deaminase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 2001

Chain	Residue
A	HIS53
A	CYS83
A	CYS86
A	HOH2002

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1001

Chain	Residue
B	PHE122
B	ASN123
A	CYS83
A	VAL84
A	GLY107
A	HOH2052
A	HOH2059

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN B 2002

Chain	Residue
B	HIS53
B	GLU55
B	CYS83
B	CYS86
B	HOH2003

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 1002

Chain	Residue
A	PHE122
A	ASN123
B	CYS83
B	VAL84
B	GLY107
B	HOH2041
B	HOH2042

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 2003

Chain	Residue
C	HIS53
C	CYS83
C	CYS86
C	HOH2004

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 1004

Chain	Residue
C	CYS83
C	VAL84
C	GLY107
C	HOH2060
D	PHE122
D	ASN123

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 2004

Chain	Residue
D	HIS53
D	CYS83
D	CYS86
D	HOH2005

---

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL D 1003

Chain	Residue
C	MET92
C	PHE122
C	ASN123
D	CYS83
D	VAL84
D	GLY107
D	HOH2037
D	HOH2053
H	HOH50

---

Functional Information from PROSITE/UniProt

site_id	PS00903
Number of Residues	38
Details	CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAEhiAIeraakvlgswrlegctlyvtle...........PCvm......CagtI

Chain	Residue	Details
A	HIS53-ILE90

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_00972

Chain	Residue	Details
A	GLU55
B	GLU55
C	GLU55
D	GLU55

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00972, ECO:0000269|PubMed:16415880

Chain	Residue	Details
A	HIS53
D	HIS53
D	CYS83
D	CYS86
A	CYS83
A	CYS86
B	HIS53
B	CYS83
B	CYS86
C	HIS53
C	CYS83
C	CYS86

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