2B25
Human putative tRNA(1-methyladenosine)methyltransferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0030488 | biological_process | tRNA methylation |
| A | 0031515 | cellular_component | tRNA (m1A) methyltransferase complex |
| A | 0160107 | molecular_function | tRNA (adenine(58)-N1)-methyltransferase activity |
| B | 0030488 | biological_process | tRNA methylation |
| B | 0031515 | cellular_component | tRNA (m1A) methyltransferase complex |
| B | 0160107 | molecular_function | tRNA (adenine(58)-N1)-methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE SAM A 601 |
| Chain | Residue |
| A | THR84 |
| A | GLU135 |
| A | VAL136 |
| A | ARG137 |
| A | HIS140 |
| A | ASP173 |
| A | ILE174 |
| A | ASP192 |
| A | MET193 |
| A | UNX701 |
| A | THR87 |
| A | GLY111 |
| A | SER112 |
| A | GLY113 |
| A | SER114 |
| A | GLY115 |
| A | GLY116 |
| A | MET117 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE SAM B 602 |
| Chain | Residue |
| B | THR84 |
| B | THR87 |
| B | GLY111 |
| B | GLY113 |
| B | SER114 |
| B | GLY116 |
| B | MET117 |
| B | GLU135 |
| B | VAL136 |
| B | ARG137 |
| B | HIS140 |
| B | ASP173 |
| B | ILE174 |
| B | ASP192 |
| B | MET193 |
| B | UNX703 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE UNX A 701 |
| Chain | Residue |
| A | MET193 |
| A | LEU194 |
| A | SAM601 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX B 703 |
| Chain | Residue |
| B | LEU194 |
| B | SAM602 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNX B 704 |
| Chain | Residue |
| B | VAL218 |
| B | GLN222 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 43 |
| Details | Region: {"description":"Substrate","evidences":[{"source":"UniProtKB","id":"Q96FX7","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00952","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-2006","submissionDatabase":"PDB data bank","title":"Human putative tRNA(1-methyladenosine)methyltransferase.","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-2006","submissionDatabase":"PDB data bank","title":"Human putative tRNA(1-methyladenosine)methyltransferase.","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q96FX7","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1qam |
| Chain | Residue | Details |
| B | ASP192 | |
| B | GLY111 | |
| B | GLU135 |
