2B0F

NMR Structure of the Human Rhinovirus 3C Protease (serotype 14) with covalently bound Ace-LEALFQ-ethylpropionate inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR CHAIN B OF ACE-LEALFQ-ETHYLPROPIONATE

Chain	Residue
A	LYS22
A	LYS142
A	THR143
A	GLY144
A	CYS146
A	HIS160
A	VAL161
A	GLY162
A	GLY163
A	ASN164
A	PHE169
A	HIS40
A	GLU71
A	ILE124
A	ASN125
A	LEU126
A	SER127
A	SER128
A	THR141

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: For protease 3C activity => ECO:0000255|PROSITE-ProRule:PRU01222

Chain	Residue	Details
A	HIS40
A	GLU71
A	CYS146

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage; by protease 3C => ECO:0000250|UniProtKB:P03301

Chain	Residue	Details
A	GLN182

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1cqq

Chain	Residue	Details
A	HIS40
A	GLU71
A	GLY144
A	CYS146

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