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2B05

Crystal Structure of 14-3-3 gamma in complex with a phosphoserine peptide

Functional Information from GO Data
ChainGOidnamespacecontents
A0002842biological_processpositive regulation of T cell mediated immune response to tumor cell
A0003723molecular_functionRNA binding
A0005080molecular_functionprotein kinase C binding
A0005159molecular_functioninsulin-like growth factor receptor binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005925cellular_componentfocal adhesion
A0006469biological_processnegative regulation of protein kinase activity
A0006605biological_processprotein targeting
A0007165biological_processsignal transduction
A0008104biological_processprotein localization
A0008426molecular_functionprotein kinase C inhibitor activity
A0009966biological_processregulation of signal transduction
A0016020cellular_componentmembrane
A0019904molecular_functionprotein domain specific binding
A0022409biological_processpositive regulation of cell-cell adhesion
A0030971molecular_functionreceptor tyrosine kinase binding
A0031982cellular_componentvesicle
A0032869biological_processcellular response to insulin stimulus
A0032880biological_processregulation of protein localization
A0042149biological_processcellular response to glucose starvation
A0042802molecular_functionidentical protein binding
A0045202cellular_componentsynapse
A0045664biological_processregulation of neuron differentiation
A0048167biological_processregulation of synaptic plasticity
A0050870biological_processpositive regulation of T cell activation
A0070062cellular_componentextracellular exosome
A0098793cellular_componentpresynapse
A0140031molecular_functionphosphorylation-dependent protein binding
A0140311molecular_functionprotein sequestering activity
A1904262biological_processnegative regulation of TORC1 signaling
B0002842biological_processpositive regulation of T cell mediated immune response to tumor cell
B0003723molecular_functionRNA binding
B0005080molecular_functionprotein kinase C binding
B0005159molecular_functioninsulin-like growth factor receptor binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005925cellular_componentfocal adhesion
B0006469biological_processnegative regulation of protein kinase activity
B0006605biological_processprotein targeting
B0007165biological_processsignal transduction
B0008104biological_processprotein localization
B0008426molecular_functionprotein kinase C inhibitor activity
B0009966biological_processregulation of signal transduction
B0016020cellular_componentmembrane
B0019904molecular_functionprotein domain specific binding
B0022409biological_processpositive regulation of cell-cell adhesion
B0030971molecular_functionreceptor tyrosine kinase binding
B0031982cellular_componentvesicle
B0032869biological_processcellular response to insulin stimulus
B0032880biological_processregulation of protein localization
B0042149biological_processcellular response to glucose starvation
B0042802molecular_functionidentical protein binding
B0045202cellular_componentsynapse
B0045664biological_processregulation of neuron differentiation
B0048167biological_processregulation of synaptic plasticity
B0050870biological_processpositive regulation of T cell activation
B0070062cellular_componentextracellular exosome
B0098793cellular_componentpresynapse
B0140031molecular_functionphosphorylation-dependent protein binding
B0140311molecular_functionprotein sequestering activity
B1904262biological_processnegative regulation of TORC1 signaling
C0002842biological_processpositive regulation of T cell mediated immune response to tumor cell
C0003723molecular_functionRNA binding
C0005080molecular_functionprotein kinase C binding
C0005159molecular_functioninsulin-like growth factor receptor binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005925cellular_componentfocal adhesion
C0006469biological_processnegative regulation of protein kinase activity
C0006605biological_processprotein targeting
C0007165biological_processsignal transduction
C0008104biological_processprotein localization
C0008426molecular_functionprotein kinase C inhibitor activity
C0009966biological_processregulation of signal transduction
C0016020cellular_componentmembrane
C0019904molecular_functionprotein domain specific binding
C0022409biological_processpositive regulation of cell-cell adhesion
C0030971molecular_functionreceptor tyrosine kinase binding
C0031982cellular_componentvesicle
C0032869biological_processcellular response to insulin stimulus
C0032880biological_processregulation of protein localization
C0042149biological_processcellular response to glucose starvation
C0042802molecular_functionidentical protein binding
C0045202cellular_componentsynapse
C0045664biological_processregulation of neuron differentiation
C0048167biological_processregulation of synaptic plasticity
C0050870biological_processpositive regulation of T cell activation
C0070062cellular_componentextracellular exosome
C0098793cellular_componentpresynapse
C0140031molecular_functionphosphorylation-dependent protein binding
C0140311molecular_functionprotein sequestering activity
C1904262biological_processnegative regulation of TORC1 signaling
D0002842biological_processpositive regulation of T cell mediated immune response to tumor cell
D0003723molecular_functionRNA binding
D0005080molecular_functionprotein kinase C binding
D0005159molecular_functioninsulin-like growth factor receptor binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005925cellular_componentfocal adhesion
D0006469biological_processnegative regulation of protein kinase activity
D0006605biological_processprotein targeting
D0007165biological_processsignal transduction
D0008104biological_processprotein localization
D0008426molecular_functionprotein kinase C inhibitor activity
D0009966biological_processregulation of signal transduction
D0016020cellular_componentmembrane
D0019904molecular_functionprotein domain specific binding
D0022409biological_processpositive regulation of cell-cell adhesion
D0030971molecular_functionreceptor tyrosine kinase binding
D0031982cellular_componentvesicle
D0032869biological_processcellular response to insulin stimulus
D0032880biological_processregulation of protein localization
D0042149biological_processcellular response to glucose starvation
D0042802molecular_functionidentical protein binding
D0045202cellular_componentsynapse
D0045664biological_processregulation of neuron differentiation
D0048167biological_processregulation of synaptic plasticity
D0050870biological_processpositive regulation of T cell activation
D0070062cellular_componentextracellular exosome
D0098793cellular_componentpresynapse
D0140031molecular_functionphosphorylation-dependent protein binding
D0140311molecular_functionprotein sequestering activity
D1904262biological_processnegative regulation of TORC1 signaling
E0002842biological_processpositive regulation of T cell mediated immune response to tumor cell
E0003723molecular_functionRNA binding
E0005080molecular_functionprotein kinase C binding
E0005159molecular_functioninsulin-like growth factor receptor binding
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005925cellular_componentfocal adhesion
E0006469biological_processnegative regulation of protein kinase activity
E0006605biological_processprotein targeting
E0007165biological_processsignal transduction
E0008104biological_processprotein localization
E0008426molecular_functionprotein kinase C inhibitor activity
E0009966biological_processregulation of signal transduction
E0016020cellular_componentmembrane
E0019904molecular_functionprotein domain specific binding
E0022409biological_processpositive regulation of cell-cell adhesion
E0030971molecular_functionreceptor tyrosine kinase binding
E0031982cellular_componentvesicle
E0032869biological_processcellular response to insulin stimulus
E0032880biological_processregulation of protein localization
E0042149biological_processcellular response to glucose starvation
E0042802molecular_functionidentical protein binding
E0045202cellular_componentsynapse
E0045664biological_processregulation of neuron differentiation
E0048167biological_processregulation of synaptic plasticity
E0050870biological_processpositive regulation of T cell activation
E0070062cellular_componentextracellular exosome
E0098793cellular_componentpresynapse
E0140031molecular_functionphosphorylation-dependent protein binding
E0140311molecular_functionprotein sequestering activity
E1904262biological_processnegative regulation of TORC1 signaling
F0002842biological_processpositive regulation of T cell mediated immune response to tumor cell
F0003723molecular_functionRNA binding
F0005080molecular_functionprotein kinase C binding
F0005159molecular_functioninsulin-like growth factor receptor binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005925cellular_componentfocal adhesion
F0006469biological_processnegative regulation of protein kinase activity
F0006605biological_processprotein targeting
F0007165biological_processsignal transduction
F0008104biological_processprotein localization
F0008426molecular_functionprotein kinase C inhibitor activity
F0009966biological_processregulation of signal transduction
F0016020cellular_componentmembrane
F0019904molecular_functionprotein domain specific binding
F0022409biological_processpositive regulation of cell-cell adhesion
F0030971molecular_functionreceptor tyrosine kinase binding
F0031982cellular_componentvesicle
F0032869biological_processcellular response to insulin stimulus
F0032880biological_processregulation of protein localization
F0042149biological_processcellular response to glucose starvation
F0042802molecular_functionidentical protein binding
F0045202cellular_componentsynapse
F0045664biological_processregulation of neuron differentiation
F0048167biological_processregulation of synaptic plasticity
F0050870biological_processpositive regulation of T cell activation
F0070062cellular_componentextracellular exosome
F0098793cellular_componentpresynapse
F0140031molecular_functionphosphorylation-dependent protein binding
F0140311molecular_functionprotein sequestering activity
F1904262biological_processnegative regulation of TORC1 signaling
Functional Information from PROSITE/UniProt
site_idPS00796
Number of Residues11
Details1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
ChainResidueDetails
AARG42-VAL52

site_idPS00797
Number of Residues20
Details1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS
ChainResidueDetails
ATYR216-SER235

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsSITE: Interaction with phosphoserine on interacting protein => ECO:0000269|PubMed:17085597
ChainResidueDetails
ASER58
ETYR133
FSER58
FTYR133
ATYR133
BSER58
BTYR133
CSER58
CTYR133
DSER58
DTYR133
ESER58

site_idSWS_FT_FI2
Number of Residues6
DetailsMOD_RES: N-acetylmethionine; in 14-3-3 protein gamma; alternate; partial => ECO:0000269|Ref.7
ChainResidueDetails
AVAL2
BVAL2
CVAL2
DVAL2
EVAL2
FVAL2

site_idSWS_FT_FI3
Number of Residues6
DetailsMOD_RES: N-acetylvaline; partial => ECO:0000269|PubMed:14534293, ECO:0000269|Ref.7, ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330
ChainResidueDetails
AASP3
BASP3
CASP3
DASP3
EASP3
FASP3

site_idSWS_FT_FI4
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
AALA72
BALA72
CALA72
DALA72
EALA72
FALA72

site_idSWS_FT_FI5
Number of Residues6
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P61983
ChainResidueDetails
ALEU134
BLEU134
CLEU134
DLEU134
ELEU134
FLEU134

site_idSWS_FT_FI6
Number of Residues6
DetailsMOD_RES: Phosphothreonine => ECO:0000269|Ref.7
ChainResidueDetails
AVAL146
BVAL146
CVAL146
DVAL146
EVAL146
FVAL146

site_idSWS_FT_FI7
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P61983
ChainResidueDetails
ATYR216
BTYR216
CTYR216
DTYR216
ETYR216
FTYR216

site_idSWS_FT_FI8
Number of Residues6
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER235
BSER235
CSER235
DSER235
ESER235
FSER235

site_idSWS_FT_FI9
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
AASP236
BASP236
CASP236
DASP236
EASP236
FASP236

224201

PDB entries from 2024-08-28

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