2AY4

AROMATIC AMINO ACID AMINOTRANSFERASE WITH 3-(P-TOLYL)PROPIONIC ACID

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004069	molecular_function	L-aspartate:2-oxoglutarate aminotransferase activity
A	0004838	molecular_function	L-tyrosine:2-oxoglutarate aminotransferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006520	biological_process	amino acid metabolic process
A	0006533	biological_process	aspartate catabolic process
A	0008483	molecular_function	transaminase activity
A	0008652	biological_process	amino acid biosynthetic process
A	0008793	molecular_function	aromatic-amino-acid:2-oxoglutarate aminotransferase activity
A	0009058	biological_process	biosynthetic process
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0016740	molecular_function	transferase activity
A	0030170	molecular_function	pyridoxal phosphate binding
A	0033585	biological_process	L-phenylalanine biosynthetic process from chorismate via phenylpyruvate
A	0042802	molecular_function	identical protein binding
A	0080130	molecular_function	L-phenylalanine:2-oxoglutarate aminotransferase activity
B	0004069	molecular_function	L-aspartate:2-oxoglutarate aminotransferase activity
B	0004838	molecular_function	L-tyrosine:2-oxoglutarate aminotransferase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006520	biological_process	amino acid metabolic process
B	0006533	biological_process	aspartate catabolic process
B	0008483	molecular_function	transaminase activity
B	0008652	biological_process	amino acid biosynthetic process
B	0008793	molecular_function	aromatic-amino-acid:2-oxoglutarate aminotransferase activity
B	0009058	biological_process	biosynthetic process
B	0009073	biological_process	aromatic amino acid family biosynthetic process
B	0016740	molecular_function	transferase activity
B	0030170	molecular_function	pyridoxal phosphate binding
B	0033585	biological_process	L-phenylalanine biosynthetic process from chorismate via phenylpyruvate
B	0042802	molecular_function	identical protein binding
B	0080130	molecular_function	L-phenylalanine:2-oxoglutarate aminotransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PLP A 413

Chain	Residue
A	GLY107
A	SER257
A	LYS258
A	ARG266
B	TYR70
A	GLY108
A	THR109
A	TRP140
A	ASN194
A	ASP222
A	ALA224
A	TYR225
A	SER255

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site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PLP B 413

Chain	Residue
A	TYR70
B	GLY108
B	THR109
B	TRP140
B	ASN194
B	ASP222
B	ALA224
B	TYR225
B	SER255
B	SER257
B	LYS258
B	ARG266

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site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PPT B 414

Chain	Residue
A	TYR70
A	SER296
B	ILE17
B	LEU18
B	GLY38
B	TRP140
B	ASN142
B	ASN194
B	LYS258
B	ARG386

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	BINDING:

Chain	Residue	Details
A	GLY38
B	ARG386
A	TYR70
A	TRP140
A	ASN194
A	ARG386
B	GLY38
B	TYR70
B	TRP140
B	ASN194

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-(pyridoxal phosphate)lysine

Chain	Residue	Details
A	LYS258
B	LYS258

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 411

Chain	Residue	Details
A	TRP140	steric role
A	ASP222	electrostatic stabiliser
A	ALA224	steric role
A	LYS258	covalent catalysis, proton shuttle (general acid/base)

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site_id	MCSA2
Number of Residues	4
Details	M-CSA 411

Chain	Residue	Details
B	TRP140	steric role
B	ASP222	electrostatic stabiliser
B	ALA224	steric role
B	LYS258	covalent catalysis, proton shuttle (general acid/base)

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