Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 201 |
| Chain | Residue |
| A | PRO39 |
| A | GLY40 |
| A | HOH1149 |
| A | HOH1170 |
| A | HOH1269 |
| A | HOH1302 |
| B | MET36 |
| B | SER37 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 501 |
| Chain | Residue |
| A | LYS55 |
| A | HOH1124 |
| A | HOH1157 |
| A | HOH1199 |
| A | HOH1244 |
| A | HOH1245 |
| B | HIS69 |
| B | LYS70 |
| A | PRO1 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 B 703 |
| Chain | Residue |
| B | PRO1 |
| B | ARG57 |
| B | HIS69 |
| B | HOH1095 |
| B | HOH1134 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DMS B 401 |
| Chain | Residue |
| A | GLY17 |
| B | LYS14 |
| B | GLY16 |
| B | GLY17 |
| B | ILE63 |
| B | GLU65 |
| B | ACY605 |
| site_id | AC5 |
| Number of Residues | 39 |
| Details | BINDING SITE FOR RESIDUE MK1 B 902 |
| Chain | Residue |
| A | ARG8 |
| A | ASP25 |
| A | GLY27 |
| A | ALA28 |
| A | ASP29 |
| A | ASP30 |
| A | VAL32 |
| A | ILE47 |
| A | GLY48 |
| A | GLY49 |
| A | VAL50 |
| A | PRO81 |
| A | VAL82 |
| A | HOH1307 |
| B | ARG8 |
| B | LEU23 |
| B | ASP25 |
| B | GLY27 |
| B | ALA28 |
| B | ASP29 |
| B | ASP30 |
| B | VAL32 |
| B | ILE47 |
| B | GLY48 |
| B | GLY49 |
| B | PRO81 |
| B | VAL82 |
| B | ILE84 |
| B | HOH1005 |
| B | HOH1011 |
| B | HOH1024 |
| B | HOH1032 |
| B | HOH1074 |
| B | HOH1120 |
| B | HOH1140 |
| B | HOH1144 |
| B | HOH1173 |
| B | HOH1182 |
| B | HOH1283 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE ACY B 603 |
| Chain | Residue |
| A | THR4 |
| A | TRP6 |
| A | GLY51 |
| A | HOH1167 |
| B | THR91 |
| B | GLY94 |
| B | HOH1006 |
| B | HOH1041 |
| B | HOH1077 |
| B | HOH1169 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACY B 604 |
| Chain | Residue |
| B | VAL11 |
| B | THR12 |
| B | GLU21 |
| B | TRP42 |
| B | ACY606 |
| B | HOH1152 |
| B | HOH1288 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACY B 605 |
| Chain | Residue |
| A | LYS14 |
| A | ILE15 |
| A | GLY16 |
| A | GLY17 |
| A | ILE63 |
| A | HOH1259 |
| B | DMS401 |
| B | HOH1308 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ACY B 606 |
| Chain | Residue |
| B | HOH1192 |
| B | HOH1241 |
| B | HOH1288 |
| B | VAL11 |
| B | THR12 |
| B | TRP42 |
| B | ALA67 |
| B | ACY604 |
| B | HOH1152 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI |
| Chain | Residue | Details |
| A | ALA22-ILE33 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 138 |
| Details | Domain: {"description":"Peptidase A2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00275","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| A | THR26 | |
| B | ASP25 | |
| B | THR26 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| B | ASP25 | |
