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2AVM

Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, AND G73S

Functional Information from GO Data
ChainGOidnamespacecontents
A0004190molecular_functionaspartic-type endopeptidase activity
A0006508biological_processproteolysis
B0004190molecular_functionaspartic-type endopeptidase activity
B0006508biological_processproteolysis
Functional Information from PDB Data
site_idAC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE GOL A 801
ChainResidue
ALYS45
BGLN61
BGLN92
AMET46
AILE47
APHE53
AHOH1005
AHOH1013
AHOH1024
AHOH1141
AHOH1278

site_idAC2
Number of Residues32
DetailsBINDING SITE FOR RESIDUE 2NC B 300
ChainResidue
AARG8
AASP25
AGLY27
AALA28
AASP29
AGLY48
APRO81
AVAL82
AHOH1024
BARG8
BASP25
BGLY27
BALA28
BASP29
BASP30
BILE47
BGLY48
BGLY49
BILE50
BPRO81
BVAL82
BILE84
BHOH1003
BHOH1009
BHOH1018
BHOH1032
BHOH1055
BHOH1112
BHOH1154
BHOH1163
BHOH1286
BHOH1316

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ACY B 604
ChainResidue
BLYS7
BARG8
BHOH1049
BHOH1340

site_idAC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE GOL B 803
ChainResidue
AGLN18
AMET36
ASER37
BTHR12
BILE13
BLYS14
BGLU65
BALA67
BGLY68
BHOH1098

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL B 804
ChainResidue
BGLU35
BLYS55
BARG57
BVAL77
BGLY78
BHOH1167

Functional Information from PROSITE/UniProt
site_idPS00141
Number of Residues12
DetailsASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALIDTGADDTVI
ChainResidueDetails
AALA22-ILE33

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Cleavage; by viral protease => ECO:0000250
ChainResidueDetails
AILE64
BILE64

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by host => ECO:0000250
ChainResidueDetails
AILE64
BILE64

218853

PDB entries from 2024-04-24

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