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2AUZ

Cathepsin K complexed with a semicarbazone inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0006508biological_processproteolysis
A0008234molecular_functioncysteine-type peptidase activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 301
ChainResidue
ALYS122
ALYS176
AARG198
AASN199

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 302
ChainResidue
AASN187
ALYS214
AHOH335
AASN18
AARG108
AARG111
AGLY185
AGLU186

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 A 303
ChainResidue
AGLN19
AGLY23
AARG127
AHIS162
ATRP184
ACT2216
AHOH377

site_idAC4
Number of Residues13
DetailsBINDING SITE FOR RESIDUE CT2 A 216
ChainResidue
AGLN19
AGLY23
ASER24
ACYS25
ATRP26
ALYS44
AGLY65
AGLY66
AALA134
ALEU160
AASN161
AALA163
ASO4303

Functional Information from PROSITE/UniProt
site_idPS00139
Number of Residues12
DetailsTHIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGqCGSCWAfSS
ChainResidueDetails
AGLN19-SER30

site_idPS00639
Number of Residues11
DetailsTHIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LNHAVLAVGYG
ChainResidueDetails
ALEU160-GLY170

site_idPS00640
Number of Residues20
DetailsTHIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. HWIiKNSWgenWGnkGYIlM
ChainResidueDetails
AHIS177-MET196

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsActive site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1pad
ChainResidueDetails
AASN182
ACYS25
AHIS162

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1pad
ChainResidueDetails
AGLN19
ACYS25
AHIS162

site_idCSA3
Number of Residues3
DetailsAnnotated By Reference To The Literature 1pad
ChainResidueDetails
AASN182
AGLN19
AHIS162

246704

PDB entries from 2025-12-24

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