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2AUU

Inorganic pyrophosphatase complexed with magnesium pyrophosphate and fluoride

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0004427molecular_functioninorganic diphosphate phosphatase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006796biological_processphosphate-containing compound metabolic process
A0008270molecular_functionzinc ion binding
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0046872molecular_functionmetal ion binding
A0050355molecular_functioninorganic triphosphate phosphatase activity
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE MG A 201
ChainResidue
AASP65
AASP70
AASP102
APOP180
AMG202
AMG203
AF211
AHOH322

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG A 202
ChainResidue
APOP180
AMG201
AF211
AHOH308
AHOH315
AHOH353
AASP70

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 203
ChainResidue
AASP97
AASP102
APOP180
AMG201
AHOH355
AHOH364

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 204
ChainResidue
AGLU31
APOP180
AHOH378
AHOH479
AHOH480

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE NA A 206
ChainResidue
ALYS142
AGLU145
ALYS148
AHOH337
AHOH390
AHOH404

site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE NA A 207
ChainResidue
AASN24
AHOH301
AHOH310
AHOH325
AHOH347
AHOH359

site_idAC7
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL A 208
ChainResidue
AALA7
AGLY8

site_idAC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL A 209
ChainResidue
ALYS131
ATRP155

site_idAC9
Number of Residues9
DetailsBINDING SITE FOR RESIDUE F A 211
ChainResidue
AASP65
AASP67
AASP70
APOP180
AMG201
AMG202
AHOH315
AHOH322
AHOH353

site_idBC1
Number of Residues24
DetailsBINDING SITE FOR RESIDUE POP A 180
ChainResidue
ALYS29
AGLU31
AARG43
ATYR55
AASP65
AASP67
AASP70
AASP97
AASP102
ATYR141
ALYS142
AMG201
AMG202
AMG203
AMG204
AF211
AHOH308
AHOH350
AHOH353
AHOH355
AHOH364
AHOH378
AHOH479
AHOH480

Functional Information from PROSITE/UniProt
site_idPS00387
Number of Residues7
DetailsPPASE Inorganic pyrophosphatase signature. DGDPVDV
ChainResidueDetails
AASP65-VAL71

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues7
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00209
ChainResidueDetails
ATYR30
APHE44
AGLY56
AGLY66
AVAL71
AALA103
ALYS142

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1wgi
ChainResidueDetails
AASP67

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PDB entries from 2024-10-30

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