2APG

The structure of tryptophan 7-halogenase (PrnA)suggests a mechanism for regioselective chlorination

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004497	molecular_function	monooxygenase activity
A	0016491	molecular_function	oxidoreductase activity
A	0017000	biological_process	antibiotic biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL A 700

Chain	Residue
A	PRO344
A	SER347
A	THR348
A	GLY349
A	FAD600
A	HOH1081

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 701

Chain	Residue
A	HOH722
A	PRO43
A	ARG44
A	HIS165

---

site_id	AC3
Number of Residues	38
Details	BINDING SITE FOR RESIDUE FAD A 600

Chain	Residue
A	GLY12
A	GLY13
A	GLY14
A	THR15
A	ALA16
A	SER39
A	ILE42
A	ARG44
A	ILE45
A	VAL47
A	GLU49
A	ALA50
A	ASP185
A	GLU186
A	VAL187
A	CYS217
A	SER218
A	GLY219
A	ARG221
A	LEU223
A	GLY336
A	LEU337
A	PHE341
A	PRO344
A	GLY349
A	ILE350
A	CL700
A	HOH706
A	HOH707
A	HOH736
A	HOH758
A	HOH763
A	HOH780
A	HOH834
A	HOH843
A	HOH848
A	HOH1009
A	HOH1086

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18979475","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2APG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AQJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AR8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JKC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2APG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AR8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2APG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AQJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2AR8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2AR8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2AQJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18979475","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2AQJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2JKC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Site: {"description":"Role in guiding and activating HOCl"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Site: {"description":"Important for activity","evidences":[{"source":"PubMed","id":"16195462","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18979475","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---