2ANU
Crystal structure of Predicted metal-dependent phosphoesterase (PHP family) (tm0559) from THERMOTOGA MARITIMA at 2.40 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004534 | molecular_function | 5'-3' RNA exonuclease activity |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0035312 | molecular_function | 5'-3' DNA exonuclease activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004534 | molecular_function | 5'-3' RNA exonuclease activity |
| B | 0006259 | biological_process | DNA metabolic process |
| B | 0035312 | molecular_function | 5'-3' DNA exonuclease activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004534 | molecular_function | 5'-3' RNA exonuclease activity |
| C | 0006259 | biological_process | DNA metabolic process |
| C | 0035312 | molecular_function | 5'-3' DNA exonuclease activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004534 | molecular_function | 5'-3' RNA exonuclease activity |
| D | 0006259 | biological_process | DNA metabolic process |
| D | 0035312 | molecular_function | 5'-3' DNA exonuclease activity |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0004534 | molecular_function | 5'-3' RNA exonuclease activity |
| E | 0006259 | biological_process | DNA metabolic process |
| E | 0035312 | molecular_function | 5'-3' DNA exonuclease activity |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0004534 | molecular_function | 5'-3' RNA exonuclease activity |
| F | 0006259 | biological_process | DNA metabolic process |
| F | 0035312 | molecular_function | 5'-3' DNA exonuclease activity |
| F | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 405 |
| Chain | Residue |
| A | HIS13 |
| A | HIS15 |
| A | GLU97 |
| A | ASP193 |
| A | ZN705 |
| A | CL1001 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 505 |
| Chain | Residue |
| A | CL1001 |
| A | HOH1055 |
| A | ASP20 |
| A | HIS45 |
| A | HIS195 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 605 |
| Chain | Residue |
| A | ASP142 |
| A | ASP193 |
| A | CL1001 |
| A | CL1002 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 705 |
| Chain | Residue |
| A | GLU97 |
| A | HIS106 |
| A | ZN405 |
| A | CL1001 |
| A | CL1002 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN B 405 |
| Chain | Residue |
| B | HIS13 |
| B | HIS15 |
| B | GLU97 |
| B | ASP193 |
| B | ZN705 |
| B | CL1003 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 505 |
| Chain | Residue |
| B | ASP20 |
| B | HIS45 |
| B | HIS195 |
| B | CL1003 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 605 |
| Chain | Residue |
| B | ASP142 |
| B | ASP193 |
| B | CL1003 |
| B | CL1004 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 705 |
| Chain | Residue |
| B | GLU97 |
| B | HIS106 |
| B | ZN405 |
| B | CL1003 |
| B | CL1004 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN C 405 |
| Chain | Residue |
| C | HIS13 |
| C | HIS15 |
| C | GLU97 |
| C | ASP193 |
| C | ZN705 |
| C | CL1005 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 505 |
| Chain | Residue |
| C | ASP20 |
| C | HIS45 |
| C | HIS195 |
| C | CL1005 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 605 |
| Chain | Residue |
| C | ASP142 |
| C | ASP193 |
| C | CL1005 |
| C | CL1006 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN C 705 |
| Chain | Residue |
| C | GLU97 |
| C | HIS106 |
| C | ZN405 |
| C | CL1005 |
| C | CL1006 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN D 405 |
| Chain | Residue |
| D | HIS13 |
| D | HIS15 |
| D | GLU97 |
| D | ASP193 |
| D | ZN705 |
| D | CL1007 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 505 |
| Chain | Residue |
| D | ASP20 |
| D | HIS45 |
| D | HIS195 |
| D | CL1007 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 605 |
| Chain | Residue |
| D | ASP142 |
| D | ASP193 |
| D | CL1007 |
| D | CL1008 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN D 705 |
| Chain | Residue |
| D | GLU97 |
| D | HIS106 |
| D | ZN405 |
| D | CL1007 |
| D | CL1008 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN E 405 |
| Chain | Residue |
| E | HIS13 |
| E | HIS15 |
| E | GLU97 |
| E | ASP193 |
| E | ZN705 |
| E | CL1009 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN E 505 |
| Chain | Residue |
| E | ASP20 |
| E | HIS45 |
| E | HIS195 |
| E | CL1009 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN E 605 |
| Chain | Residue |
| E | ASP142 |
| E | ASP193 |
| E | CL1009 |
| E | CL1010 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN E 705 |
| Chain | Residue |
| E | GLU97 |
| E | HIS106 |
| E | ZN405 |
| E | CL1009 |
| E | CL1010 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN F 405 |
| Chain | Residue |
| F | ASP193 |
| F | ZN705 |
| F | CL1011 |
| F | HIS13 |
| F | HIS15 |
| F | GLU97 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN F 505 |
| Chain | Residue |
| F | ASP20 |
| F | HIS45 |
| F | HIS195 |
| F | CL1011 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN F 605 |
| Chain | Residue |
| F | ASP142 |
| F | ASP193 |
| F | CL1011 |
| F | CL1012 |
| site_id | CC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN F 705 |
| Chain | Residue |
| F | GLU97 |
| F | HIS106 |
| F | ZN405 |
| F | CL1011 |
| F | CL1012 |
| site_id | CC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL A 1001 |
| Chain | Residue |
| A | HIS45 |
| A | ZN405 |
| A | ZN505 |
| A | ZN605 |
| A | ZN705 |
| A | HOH1055 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 1002 |
| Chain | Residue |
| A | HIS13 |
| A | HIS140 |
| A | ASP193 |
| A | ZN605 |
| A | ZN705 |
| site_id | CC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL B 1003 |
| Chain | Residue |
| B | HIS45 |
| B | ZN405 |
| B | ZN505 |
| B | ZN605 |
| B | ZN705 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 1004 |
| Chain | Residue |
| B | HIS13 |
| B | HIS140 |
| B | ZN605 |
| B | ZN705 |
| site_id | DC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL C 1005 |
| Chain | Residue |
| C | HIS45 |
| C | ZN405 |
| C | ZN505 |
| C | ZN605 |
| C | ZN705 |
| site_id | DC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL C 1006 |
| Chain | Residue |
| C | HIS13 |
| C | HIS140 |
| C | ZN605 |
| C | ZN705 |
| site_id | DC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL D 1007 |
| Chain | Residue |
| D | HIS45 |
| D | ZN405 |
| D | ZN505 |
| D | ZN605 |
| D | ZN705 |
| site_id | DC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL D 1008 |
| Chain | Residue |
| D | HIS13 |
| D | HIS140 |
| D | ZN605 |
| D | ZN705 |
| site_id | DC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL E 1009 |
| Chain | Residue |
| E | HIS45 |
| E | HIS195 |
| E | ZN405 |
| E | ZN505 |
| E | ZN605 |
| E | ZN705 |
| site_id | DC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL E 1010 |
| Chain | Residue |
| E | HIS140 |
| E | ZN605 |
| E | ZN705 |
| site_id | DC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL F 1011 |
| Chain | Residue |
| F | HIS45 |
| F | ZN405 |
| F | ZN505 |
| F | ZN605 |
| F | ZN705 |
| site_id | DC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL F 1012 |
| Chain | Residue |
| F | HIS140 |
| F | ZN605 |
| F | ZN705 |
| site_id | EC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 1013 |
| Chain | Residue |
| A | ILE213 |
| B | ILE213 |
| site_id | EC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL C 1014 |
| Chain | Residue |
| C | ASN212 |
| C | ILE213 |
| C | HOH1015 |
| D | ILE213 |
| D | HOH1026 |
| site_id | EC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL E 1015 |
| Chain | Residue |
| E | ILE213 |
| F | ILE213 |
| F | HOH1037 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. SDFHELWHVY |
| Chain | Residue | Details |
| A | SER192-TYR201 |
