2ALB

NMR structure of the N-terminal domain a of the glycoprotein chaperone ERp57

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003756	molecular_function	protein disulfide isomerase activity
A	0015035	molecular_function	protein-disulfide reductase activity

Functional Information from PROSITE/UniProt

site_id	PS00194
Number of Residues	19
Details	THIOREDOXIN_1 Thioredoxin family active site. LVeFFapWCGHCKrLapeY

Chain	Residue	Details
A	LEU25-TYR43

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:11825568, ECO:0000269|PubMed:16193070, ECO:0000269|PubMed:19119025

Chain	Residue	Details
A	CYS33
A	CYS36

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Contributes to redox potential value => ECO:0000250

Chain	Residue	Details
A	GLY34
A	HIS35

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Lowers pKa of C-terminal Cys of first active site => ECO:0000250

Chain	Residue	Details
A	ARG95

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-methyllysine => ECO:0007744|PubMed:24129315

Chain	Residue	Details
A	LYS37

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P27773

Chain	Residue	Details
A	LYS105

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1mek

Chain	Residue	Details
A	GLY34
A	HIS35
A	CYS33
A	CYS36

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1mek

Chain	Residue	Details
A	CYS33
A	CYS36

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