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2AJD

Porcine dipeptidyl peptidase IV (CD26) in complex with L-Pro-boro-L-Pro (boroPro)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001618molecular_functionvirus receptor activity
A0001662biological_processbehavioral fear response
A0001666biological_processresponse to hypoxia
A0002020molecular_functionprotease binding
A0004177molecular_functionaminopeptidase activity
A0004252molecular_functionserine-type endopeptidase activity
A0005102molecular_functionsignaling receptor binding
A0005576cellular_componentextracellular region
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0007155biological_processcell adhesion
A0008236molecular_functionserine-type peptidase activity
A0008239molecular_functiondipeptidyl-peptidase activity
A0008284biological_processpositive regulation of cell population proliferation
A0009986cellular_componentcell surface
A0010716biological_processnegative regulation of extracellular matrix disassembly
A0016324cellular_componentapical plasma membrane
A0030027cellular_componentlamellipodium
A0030139cellular_componentendocytic vesicle
A0031258cellular_componentlamellipodium membrane
A0031295biological_processT cell costimulation
A0033632biological_processregulation of cell-cell adhesion mediated by integrin
A0035641biological_processlocomotory exploration behavior
A0036343biological_processpsychomotor behavior
A0042110biological_processT cell activation
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042995cellular_componentcell projection
A0043542biological_processendothelial cell migration
A0045121cellular_componentmembrane raft
A0045499molecular_functionchemorepellent activity
A0046581cellular_componentintercellular canaliculus
A0046718biological_processsymbiont entry into host cell
A0050919biological_processnegative chemotaxis
A0070161cellular_componentanchoring junction
A0090024biological_processnegative regulation of neutrophil chemotaxis
B0001618molecular_functionvirus receptor activity
B0001662biological_processbehavioral fear response
B0001666biological_processresponse to hypoxia
B0002020molecular_functionprotease binding
B0004177molecular_functionaminopeptidase activity
B0004252molecular_functionserine-type endopeptidase activity
B0005102molecular_functionsignaling receptor binding
B0005576cellular_componentextracellular region
B0005886cellular_componentplasma membrane
B0006508biological_processproteolysis
B0007155biological_processcell adhesion
B0008236molecular_functionserine-type peptidase activity
B0008239molecular_functiondipeptidyl-peptidase activity
B0008284biological_processpositive regulation of cell population proliferation
B0009986cellular_componentcell surface
B0010716biological_processnegative regulation of extracellular matrix disassembly
B0016324cellular_componentapical plasma membrane
B0030027cellular_componentlamellipodium
B0030139cellular_componentendocytic vesicle
B0031258cellular_componentlamellipodium membrane
B0031295biological_processT cell costimulation
B0033632biological_processregulation of cell-cell adhesion mediated by integrin
B0035641biological_processlocomotory exploration behavior
B0036343biological_processpsychomotor behavior
B0042110biological_processT cell activation
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042995cellular_componentcell projection
B0043542biological_processendothelial cell migration
B0045121cellular_componentmembrane raft
B0045499molecular_functionchemorepellent activity
B0046581cellular_componentintercellular canaliculus
B0046718biological_processsymbiont entry into host cell
B0050919biological_processnegative chemotaxis
B0070161cellular_componentanchoring junction
B0090024biological_processnegative regulation of neutrophil chemotaxis
C0001618molecular_functionvirus receptor activity
C0001662biological_processbehavioral fear response
C0001666biological_processresponse to hypoxia
C0002020molecular_functionprotease binding
C0004177molecular_functionaminopeptidase activity
C0004252molecular_functionserine-type endopeptidase activity
C0005102molecular_functionsignaling receptor binding
C0005576cellular_componentextracellular region
C0005886cellular_componentplasma membrane
C0006508biological_processproteolysis
C0007155biological_processcell adhesion
C0008236molecular_functionserine-type peptidase activity
C0008239molecular_functiondipeptidyl-peptidase activity
C0008284biological_processpositive regulation of cell population proliferation
C0009986cellular_componentcell surface
C0010716biological_processnegative regulation of extracellular matrix disassembly
C0016324cellular_componentapical plasma membrane
C0030027cellular_componentlamellipodium
C0030139cellular_componentendocytic vesicle
C0031258cellular_componentlamellipodium membrane
C0031295biological_processT cell costimulation
C0033632biological_processregulation of cell-cell adhesion mediated by integrin
C0035641biological_processlocomotory exploration behavior
C0036343biological_processpsychomotor behavior
C0042110biological_processT cell activation
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0042995cellular_componentcell projection
C0043542biological_processendothelial cell migration
C0045121cellular_componentmembrane raft
C0045499molecular_functionchemorepellent activity
C0046581cellular_componentintercellular canaliculus
C0046718biological_processsymbiont entry into host cell
C0050919biological_processnegative chemotaxis
C0070161cellular_componentanchoring junction
C0090024biological_processnegative regulation of neutrophil chemotaxis
D0001618molecular_functionvirus receptor activity
D0001662biological_processbehavioral fear response
D0001666biological_processresponse to hypoxia
D0002020molecular_functionprotease binding
D0004177molecular_functionaminopeptidase activity
D0004252molecular_functionserine-type endopeptidase activity
D0005102molecular_functionsignaling receptor binding
D0005576cellular_componentextracellular region
D0005886cellular_componentplasma membrane
D0006508biological_processproteolysis
D0007155biological_processcell adhesion
D0008236molecular_functionserine-type peptidase activity
D0008239molecular_functiondipeptidyl-peptidase activity
D0008284biological_processpositive regulation of cell population proliferation
D0009986cellular_componentcell surface
D0010716biological_processnegative regulation of extracellular matrix disassembly
D0016324cellular_componentapical plasma membrane
D0030027cellular_componentlamellipodium
D0030139cellular_componentendocytic vesicle
D0031258cellular_componentlamellipodium membrane
D0031295biological_processT cell costimulation
D0033632biological_processregulation of cell-cell adhesion mediated by integrin
D0035641biological_processlocomotory exploration behavior
D0036343biological_processpsychomotor behavior
D0042110biological_processT cell activation
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0042995cellular_componentcell projection
D0043542biological_processendothelial cell migration
D0045121cellular_componentmembrane raft
D0045499molecular_functionchemorepellent activity
D0046581cellular_componentintercellular canaliculus
D0046718biological_processsymbiont entry into host cell
D0050919biological_processnegative chemotaxis
D0070161cellular_componentanchoring junction
D0090024biological_processnegative regulation of neutrophil chemotaxis
Functional Information from PROSITE/UniProt
site_idPS00708
Number of Residues31
DetailsPRO_ENDOPEP_SER Prolyl endopeptidase family serine active site. DqieAtrqFskmgfvddkriaiwGwSyGGYV
ChainResidueDetails
AASP605-VAL635

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU10084
ChainResidueDetails
ASER630
DSER630
DASP708
DHIS740
AASP708
AHIS740
BSER630
BASP708
BHIS740
CSER630
CASP708
CHIS740

site_idSWS_FT_FI2
Number of Residues24
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12690074
ChainResidueDetails
AASN85
BASN279
BASN321
BASN685
CASN85
CASN92
CASN229
CASN279
CASN321
CASN685
DASN85
AASN92
DASN92
DASN229
DASN279
DASN321
DASN685
AASN229
AASN279
AASN321
AASN685
BASN85
BASN92
BASN229

site_idSWS_FT_FI3
Number of Residues12
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498
ChainResidueDetails
AASN150
DASN150
DASN179
DASN219
AASN179
AASN219
BASN150
BASN179
BASN219
CASN150
CASN179
CASN219

Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1pfq
ChainResidueDetails
AHIS740
AASP708
ASER630

site_idCSA2
Number of Residues3
DetailsAnnotated By Reference To The Literature 1pfq
ChainResidueDetails
BHIS740
BASP708
BSER630

site_idCSA3
Number of Residues3
DetailsAnnotated By Reference To The Literature 1pfq
ChainResidueDetails
CHIS740
CASP708
CSER630

site_idCSA4
Number of Residues3
DetailsAnnotated By Reference To The Literature 1pfq
ChainResidueDetails
DHIS740
DASP708
DSER630

227344

PDB entries from 2024-11-13

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