2AIG

ADAMALYSIN II WITH PEPTIDOMIMETIC INHIBITOR POL647

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0004222	molecular_function	metalloendopeptidase activity
P	0005576	cellular_component	extracellular region
P	0005886	cellular_component	plasma membrane
P	0006508	biological_process	proteolysis
P	0008233	molecular_function	peptidase activity
P	0008237	molecular_function	metallopeptidase activity
P	0016787	molecular_function	hydrolase activity
P	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 0GR P 203

Chain	Residue
P	GLY105
P	ARG167
P	PRO168
P	GLY169
P	LEU170
P	ZN999
P	LYS106
P	ILE107
P	ILE108
P	GLY109
P	THR139
P	HIS142
P	GLU143
P	ILE165

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN P 999

Chain	Residue
P	HIS142
P	HIS146
P	HIS152
P	0GR203

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA P 250

Chain	Residue
P	GLU9
P	ASP93
P	GLN196
P	CYS197
P	ASN200
P	HOH313

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 P 260

Chain	Residue
P	ARG6
P	LEU199
P	HOH379

---

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TMAHELGHNL

Chain	Residue	Details
P	THR139-LEU148

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00276","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9521103","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {}

Chain

Residue

Details

---