2AIG

ADAMALYSIN II WITH PEPTIDOMIMETIC INHIBITOR POL647

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0004222	molecular_function	metalloendopeptidase activity
P	0005576	cellular_component	extracellular region
P	0005886	cellular_component	plasma membrane
P	0006508	biological_process	proteolysis
P	0008237	molecular_function	metallopeptidase activity
P	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 0GR P 203

Chain	Residue
P	GLY105
P	ARG167
P	PRO168
P	GLY169
P	LEU170
P	ZN999
P	LYS106
P	ILE107
P	ILE108
P	GLY109
P	THR139
P	HIS142
P	GLU143
P	ILE165

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN P 999

Chain	Residue
P	HIS142
P	HIS146
P	HIS152
P	0GR203

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA P 250

Chain	Residue
P	GLU9
P	ASP93
P	GLN196
P	CYS197
P	ASN200
P	HOH313

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site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 P 260

Chain	Residue
P	ARG6
P	LEU199
P	HOH379

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Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TMAHELGHNL

Chain	Residue	Details
P	THR139-LEU148

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095

Chain	Residue	Details
P	GLU143

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:9521103

Chain	Residue	Details
P	GLU9
P	ASP93
P	CYS197
P	ASN200

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site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
P	HIS142
P	HIS146
P	HIS152

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