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2AI6

Solution structure of human phosphohistidine phosphatase 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0004721molecular_functionphosphoprotein phosphatase activity
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006470biological_processprotein dephosphorylation
A0016604cellular_componentnuclear body
A0019855molecular_functioncalcium channel inhibitor activity
A0030036biological_processactin cytoskeleton organization
A0035971biological_processpeptidyl-histidine dephosphorylation
A0044325molecular_functiontransmembrane transporter binding
A0050860biological_processnegative regulation of T cell receptor signaling pathway
A0051015molecular_functionactin filament binding
A0051350biological_processnegative regulation of lyase activity
A0061851cellular_componentleading edge of lamellipodium
A0070062cellular_componentextracellular exosome
A0097581biological_processlamellipodium organization
A0101006molecular_functionprotein histidine phosphatase activity
A2000147biological_processpositive regulation of cell motility
A2000984biological_processnegative regulation of ATP citrate synthase activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000269|PubMed:18991813
ChainResidueDetails
AHIS53

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000305|PubMed:18991813
ChainResidueDetails
ALYS21
ASER94

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
ChainResidueDetails
AALA2

Catalytic Information from CSA
site_idMCSA1
Number of Residues6
DetailsM-CSA 952
ChainResidueDetails
ALYS21electrostatic stabiliser, modifies pKa
AHIS53proton acceptor, proton donor
AALA54electrostatic stabiliser
AARG78electrostatic stabiliser
ASER94electrostatic stabiliser
AALA96electrostatic stabiliser

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PDB entries from 2024-11-06

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