2AI2

Purine nucleoside phosphorylase from calf spleen

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004731	molecular_function	purine-nucleoside phosphorylase activity
A	0005737	cellular_component	cytoplasm
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006166	biological_process	purine ribonucleoside salvage
A	0009116	biological_process	nucleoside metabolic process
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0047975	molecular_function	guanosine phosphorylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 290

Chain	Residue
A	HOH2000
A	HOH2001
A	HOH2002
A	HOH2003
A	HOH2007

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 291

Chain	Residue
A	HIS20
A	HIS20
A	HIS20

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 144 A 292

Chain	Residue
A	GLU52
A	HOH2014
A	HOH2040
A	HOH2040
A	HOH2101
A	HOH2101
A	HOH2152
A	GLU52

---

site_id	AC4
Number of Residues	19
Details	BINDING SITE FOR RESIDUE P1D A 293

Chain	Residue
A	SER33
A	ARG84
A	HIS86
A	TYR88
A	ASN115
A	ALA116
A	GLY118
A	PHE200
A	GLU201
A	MET219
A	SER220
A	THR242
A	ASN243
A	HIS257
A	VAL260
A	HOH2004
A	HOH2058
A	HOH2080
A	HOH2092

---

Functional Information from PROSITE/UniProt

site_id	PS01240
Number of Residues	42
Details	PNP_MTAP_2 Purine and other phosphorylases family 2 signature. VmmqGrfHmYegypFwkvTfpVrVfrllGvet.LVvtNAaGGL

Chain	Residue	Details
A	VAL79-LEU120

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9O, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP

Chain	Residue	Details
A	SER33

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP

Chain	Residue	Details
A	HIS64

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9O, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9Q, ECO:0007744|PDB:1A9R, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T, ECO:0007744|PDB:3PNP, ECO:0007744|PDB:4PNP

Chain	Residue	Details
A	ARG84
A	ALA116
A	SER220

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:9585525, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9S, ECO:0007744|PDB:1A9T

Chain	Residue	Details
A	TYR88
A	MET219
A	HIS257

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:9585525, ECO:0000305|PubMed:9020983, ECO:0007744|PDB:1A9P, ECO:0007744|PDB:1A9Q, ECO:0007744|PDB:1A9R, ECO:0007744|PDB:1VFN

Chain	Residue	Details
A	GLU201
A	ASN243

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	SITE: Important for substrate specificity => ECO:0000250|UniProtKB:P00491

Chain	Residue	Details
A	ASN243

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P00491

Chain	Residue	Details
A	MET1

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P00491

Chain	Residue	Details
A	SER251

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1cg6

Chain	Residue	Details
A	ASN243
A	HIS86
A	GLU89

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1cg6

Chain	Residue	Details
A	ASN243
A	ASP248

---