2AHR
Crystal Structures of 1-Pyrroline-5-Carboxylate Reductase from Human Pathogen Streptococcus pyogenes
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004735 | molecular_function | pyrroline-5-carboxylate reductase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006561 | biological_process | proline biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0055129 | biological_process | L-proline biosynthetic process |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004735 | molecular_function | pyrroline-5-carboxylate reductase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006561 | biological_process | proline biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0055129 | biological_process | L-proline biosynthetic process |
C | 0000166 | molecular_function | nucleotide binding |
C | 0004735 | molecular_function | pyrroline-5-carboxylate reductase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0006561 | biological_process | proline biosynthetic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0055129 | biological_process | L-proline biosynthetic process |
D | 0000166 | molecular_function | nucleotide binding |
D | 0004735 | molecular_function | pyrroline-5-carboxylate reductase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0006561 | biological_process | proline biosynthetic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0055129 | biological_process | L-proline biosynthetic process |
E | 0000166 | molecular_function | nucleotide binding |
E | 0004735 | molecular_function | pyrroline-5-carboxylate reductase activity |
E | 0005737 | cellular_component | cytoplasm |
E | 0006561 | biological_process | proline biosynthetic process |
E | 0016491 | molecular_function | oxidoreductase activity |
E | 0055129 | biological_process | L-proline biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE NA A 1257 |
Chain | Residue |
A | GLY89 |
A | ARG94 |
A | ALA253 |
A | LYS254 |
A | LEU256 |
A | HOH1509 |
A | HOH1579 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE NA B 1258 |
Chain | Residue |
B | ALA253 |
B | LYS254 |
B | LEU256 |
B | HOH1511 |
B | HOH1566 |
B | GLY89 |
B | ARG94 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA C 1259 |
Chain | Residue |
C | GLY89 |
C | ALA253 |
C | LYS254 |
C | LEU256 |
C | HOH1511 |
C | HOH1574 |
site_id | AC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE NA D 1260 |
Chain | Residue |
D | GLY89 |
D | ARG94 |
D | ALA253 |
D | LYS254 |
D | LEU256 |
D | HOH1656 |
D | HOH1657 |
site_id | AC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE NA E 1261 |
Chain | Residue |
E | GLY89 |
E | ARG94 |
E | ALA253 |
E | LYS254 |
E | LEU256 |
E | HOH1583 |
E | HOH1590 |
site_id | AC6 |
Number of Residues | 33 |
Details | BINDING SITE FOR RESIDUE NAP A 1500 |
Chain | Residue |
A | GLY7 |
A | VAL8 |
A | GLY9 |
A | LYS10 |
A | MSE11 |
A | GLY30 |
A | SER31 |
A | ARG35 |
A | HIS51 |
A | GLY64 |
A | ILE65 |
A | LYS66 |
A | PRO67 |
A | LEU69 |
A | VAL73 |
A | MSE86 |
A | ALA87 |
A | ALA88 |
A | MSE109 |
A | PRO110 |
A | MSE112 |
A | HOH1527 |
A | HOH1529 |
A | HOH1574 |
A | HOH1578 |
A | HOH1605 |
A | HOH1635 |
A | HOH1637 |
A | HOH1646 |
D | ALA218 |
D | ILE219 |
D | SER221 |
D | HOH1637 |
site_id | AC7 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE NAP B 1501 |
Chain | Residue |
B | GLY7 |
B | VAL8 |
B | GLY9 |
B | LYS10 |
B | MSE11 |
B | GLY30 |
B | SER31 |
B | ARG35 |
B | HIS51 |
B | GLY64 |
B | ILE65 |
B | LYS66 |
B | PRO67 |
B | LEU69 |
B | MSE86 |
B | ALA87 |
B | ALA88 |
B | MSE109 |
B | PRO110 |
B | HOH1520 |
B | HOH1535 |
B | HOH1586 |
B | HOH1589 |
B | HOH1632 |
C | ILE219 |
C | SER221 |
site_id | AC8 |
Number of Residues | 28 |
Details | BINDING SITE FOR RESIDUE NAP C 1502 |
Chain | Residue |
C | GLY9 |
C | LYS10 |
C | MSE11 |
C | GLY30 |
C | SER31 |
C | ARG35 |
C | HIS51 |
C | GLY64 |
C | ILE65 |
C | LYS66 |
C | PRO67 |
C | VAL73 |
C | MSE86 |
C | ALA87 |
C | ALA88 |
C | MSE109 |
C | PRO110 |
C | MSE112 |
C | HOH1525 |
C | HOH1533 |
C | HOH1580 |
C | HOH1601 |
B | ALA218 |
B | ILE219 |
B | SER221 |
B | PRO222 |
B | HOH1628 |
C | VAL8 |
site_id | AC9 |
Number of Residues | 33 |
Details | BINDING SITE FOR RESIDUE NAP D 1503 |
Chain | Residue |
A | ALA218 |
A | ILE219 |
A | SER221 |
D | GLY7 |
D | VAL8 |
D | GLY9 |
D | LYS10 |
D | MSE11 |
D | GLY30 |
D | SER31 |
D | ARG35 |
D | HIS51 |
D | GLY64 |
D | ILE65 |
D | LYS66 |
D | PRO67 |
D | LEU69 |
D | VAL73 |
D | MSE86 |
D | ALA87 |
D | ALA88 |
D | MSE109 |
D | PRO110 |
D | MSE112 |
D | HOH1517 |
D | HOH1520 |
D | HOH1521 |
D | HOH1577 |
D | HOH1594 |
D | HOH1614 |
D | HOH1617 |
D | HOH1648 |
D | HOH1660 |
site_id | BC1 |
Number of Residues | 29 |
Details | BINDING SITE FOR RESIDUE NAP E 1504 |
Chain | Residue |
E | GLY7 |
E | GLY9 |
E | LYS10 |
E | MSE11 |
E | GLY30 |
E | SER31 |
E | ARG35 |
E | HIS51 |
E | GLY64 |
E | ILE65 |
E | LYS66 |
E | PRO67 |
E | LEU69 |
E | MSE86 |
E | ALA87 |
E | ALA88 |
E | MSE109 |
E | PRO110 |
E | MSE112 |
E | ILE219 |
E | SER221 |
E | HOH1517 |
E | HOH1554 |
E | HOH1596 |
E | HOH1606 |
E | HOH1629 |
E | HOH1632 |
E | HOH1633 |
E | HOH1664 |
site_id | BC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE FMT A 1508 |
Chain | Residue |
A | ASP251 |
A | LYS254 |
site_id | BC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE FMT B 1509 |
Chain | Residue |
B | ILE250 |
B | ASP251 |
B | LYS254 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE FMT C 1510 |
Chain | Residue |
B | ASN183 |
C | ILE250 |
C | ASP251 |
C | LYS254 |
site_id | BC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE FMT D 1511 |
Chain | Residue |
D | ILE250 |
D | ASP251 |
D | LYS254 |
site_id | BC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE FMT E 1512 |
Chain | Residue |
E | ILE250 |
E | ASP251 |
E | LYS254 |