2AH4

guanidinobenzoyl-trypsin acyl-enzyme at 1.13 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0004175	molecular_function	endopeptidase activity
X	0004252	molecular_function	serine-type endopeptidase activity
X	0005515	molecular_function	protein binding
X	0005576	cellular_component	extracellular region
X	0005615	cellular_component	extracellular space
X	0006508	biological_process	proteolysis
X	0007586	biological_process	digestion
X	0008233	molecular_function	peptidase activity
X	0008236	molecular_function	serine-type peptidase activity
X	0016787	molecular_function	hydrolase activity
X	0046872	molecular_function	metal ion binding
X	0097180	cellular_component	serine protease inhibitor complex
X	0097655	molecular_function	serpin family protein binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA X 501

Chain	Residue
X	GLU70
X	ASN72
X	VAL75
X	GLU80
X	HOH1200
X	HOH1212

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 X 802

Chain	Residue
X	SER147
X	GLY148
X	LYS204
X	HOH1237
X	HOH1282
X	HOH1416
X	PRO124
X	THR125
X	SER127

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 X 803

Chain	Residue
X	ASN95
X	THR98
X	ASN100
X	HOH1295
X	HOH1324

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site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 X 804

Chain	Residue
X	LYS145
X	SER146
X	SER147

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site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 X 805

Chain	Residue
X	LYS87
X	LYS107
X	THR149
X	TYR151
X	HOH1273
X	HOH1276
X	HOH1497
X	HOH1500
X	HOH1540

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site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GBS X 1195

Chain	Residue
X	ASP189
X	SER190
X	CYS191
X	GLN192
X	GLY193
X	SER195
X	VAL213
X	SER214
X	TRP215
X	GLY216
X	GLY219
X	GLY226

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Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
X	VAL53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV

Chain	Residue	Details
X	ASP189-VAL200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	220
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
X	ASP102
X	HIS57

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
X	SER195
X	GLY196

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
X	SER195
X	GLY193

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
X	ASP102
X	SER195
X	HIS57

---

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
X	ASP102
X	SER195
X	GLY193
X	HIS57

---

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
X	ASP102
X	SER195
X	HIS57
X	GLY196

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