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2AFG

2.0 ANGSTROM X-RAY STRUCTURE OF HUMAN ACIDIC FIBROBLAST GROWTH FACTOR

Replaces:  1AFG
Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001759biological_processorgan induction
A0001934biological_processpositive regulation of protein phosphorylation
A0005104molecular_functionfibroblast growth factor receptor binding
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005938cellular_componentcell cortex
A0007165biological_processsignal transduction
A0008083molecular_functiongrowth factor activity
A0008201molecular_functionheparin binding
A0008284biological_processpositive regulation of cell population proliferation
A0008543biological_processfibroblast growth factor receptor signaling pathway
A0009653biological_processanatomical structure morphogenesis
A0009887biological_processanimal organ morphogenesis
A0010595biological_processpositive regulation of endothelial cell migration
A0010628biological_processpositive regulation of gene expression
A0030154biological_processcell differentiation
A0030324biological_processlung development
A0030334biological_processregulation of cell migration
A0030335biological_processpositive regulation of cell migration
A0030544molecular_functionHsp70 protein binding
A0031012cellular_componentextracellular matrix
A0032148biological_processactivation of protein kinase B activity
A0034605biological_processcellular response to heat
A0042060biological_processwound healing
A0043406biological_processpositive regulation of MAP kinase activity
A0044548molecular_functionS100 protein binding
A0045542biological_processpositive regulation of cholesterol biosynthetic process
A0045766biological_processpositive regulation of angiogenesis
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0050673biological_processepithelial cell proliferation
A0050679biological_processpositive regulation of epithelial cell proliferation
A0051781biological_processpositive regulation of cell division
A0060681biological_processbranch elongation involved in ureteric bud branching
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0072163biological_processmesonephric epithelium development
A1901509biological_processregulation of endothelial tube morphogenesis
A1902533biological_processpositive regulation of intracellular signal transduction
A1903672biological_processpositive regulation of sprouting angiogenesis
A2000347biological_processpositive regulation of hepatocyte proliferation
A2000544biological_processregulation of endothelial cell chemotaxis to fibroblast growth factor
B0001525biological_processangiogenesis
B0001759biological_processorgan induction
B0001934biological_processpositive regulation of protein phosphorylation
B0005104molecular_functionfibroblast growth factor receptor binding
B0005178molecular_functionintegrin binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005938cellular_componentcell cortex
B0007165biological_processsignal transduction
B0008083molecular_functiongrowth factor activity
B0008201molecular_functionheparin binding
B0008284biological_processpositive regulation of cell population proliferation
B0008543biological_processfibroblast growth factor receptor signaling pathway
B0009653biological_processanatomical structure morphogenesis
B0009887biological_processanimal organ morphogenesis
B0010595biological_processpositive regulation of endothelial cell migration
B0010628biological_processpositive regulation of gene expression
B0030154biological_processcell differentiation
B0030324biological_processlung development
B0030334biological_processregulation of cell migration
B0030335biological_processpositive regulation of cell migration
B0030544molecular_functionHsp70 protein binding
B0031012cellular_componentextracellular matrix
B0032148biological_processactivation of protein kinase B activity
B0034605biological_processcellular response to heat
B0042060biological_processwound healing
B0043406biological_processpositive regulation of MAP kinase activity
B0044548molecular_functionS100 protein binding
B0045542biological_processpositive regulation of cholesterol biosynthetic process
B0045766biological_processpositive regulation of angiogenesis
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0050673biological_processepithelial cell proliferation
B0050679biological_processpositive regulation of epithelial cell proliferation
B0051781biological_processpositive regulation of cell division
B0060681biological_processbranch elongation involved in ureteric bud branching
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0072163biological_processmesonephric epithelium development
B1901509biological_processregulation of endothelial tube morphogenesis
B1902533biological_processpositive regulation of intracellular signal transduction
B1903672biological_processpositive regulation of sprouting angiogenesis
B2000347biological_processpositive regulation of hepatocyte proliferation
B2000544biological_processregulation of endothelial cell chemotaxis to fibroblast growth factor
C0001525biological_processangiogenesis
C0001759biological_processorgan induction
C0001934biological_processpositive regulation of protein phosphorylation
C0005104molecular_functionfibroblast growth factor receptor binding
C0005178molecular_functionintegrin binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005938cellular_componentcell cortex
C0007165biological_processsignal transduction
C0008083molecular_functiongrowth factor activity
C0008201molecular_functionheparin binding
C0008284biological_processpositive regulation of cell population proliferation
C0008543biological_processfibroblast growth factor receptor signaling pathway
C0009653biological_processanatomical structure morphogenesis
C0009887biological_processanimal organ morphogenesis
C0010595biological_processpositive regulation of endothelial cell migration
C0010628biological_processpositive regulation of gene expression
C0030154biological_processcell differentiation
C0030324biological_processlung development
C0030334biological_processregulation of cell migration
C0030335biological_processpositive regulation of cell migration
C0030544molecular_functionHsp70 protein binding
C0031012cellular_componentextracellular matrix
C0032148biological_processactivation of protein kinase B activity
C0034605biological_processcellular response to heat
C0042060biological_processwound healing
C0043406biological_processpositive regulation of MAP kinase activity
C0044548molecular_functionS100 protein binding
C0045542biological_processpositive regulation of cholesterol biosynthetic process
C0045766biological_processpositive regulation of angiogenesis
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0050673biological_processepithelial cell proliferation
C0050679biological_processpositive regulation of epithelial cell proliferation
C0051781biological_processpositive regulation of cell division
C0060681biological_processbranch elongation involved in ureteric bud branching
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0072163biological_processmesonephric epithelium development
C1901509biological_processregulation of endothelial tube morphogenesis
C1902533biological_processpositive regulation of intracellular signal transduction
C1903672biological_processpositive regulation of sprouting angiogenesis
C2000347biological_processpositive regulation of hepatocyte proliferation
C2000544biological_processregulation of endothelial cell chemotaxis to fibroblast growth factor
D0001525biological_processangiogenesis
D0001759biological_processorgan induction
D0001934biological_processpositive regulation of protein phosphorylation
D0005104molecular_functionfibroblast growth factor receptor binding
D0005178molecular_functionintegrin binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005938cellular_componentcell cortex
D0007165biological_processsignal transduction
D0008083molecular_functiongrowth factor activity
D0008201molecular_functionheparin binding
D0008284biological_processpositive regulation of cell population proliferation
D0008543biological_processfibroblast growth factor receptor signaling pathway
D0009653biological_processanatomical structure morphogenesis
D0009887biological_processanimal organ morphogenesis
D0010595biological_processpositive regulation of endothelial cell migration
D0010628biological_processpositive regulation of gene expression
D0030154biological_processcell differentiation
D0030324biological_processlung development
D0030334biological_processregulation of cell migration
D0030335biological_processpositive regulation of cell migration
D0030544molecular_functionHsp70 protein binding
D0031012cellular_componentextracellular matrix
D0032148biological_processactivation of protein kinase B activity
D0034605biological_processcellular response to heat
D0042060biological_processwound healing
D0043406biological_processpositive regulation of MAP kinase activity
D0044548molecular_functionS100 protein binding
D0045542biological_processpositive regulation of cholesterol biosynthetic process
D0045766biological_processpositive regulation of angiogenesis
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0050673biological_processepithelial cell proliferation
D0050679biological_processpositive regulation of epithelial cell proliferation
D0051781biological_processpositive regulation of cell division
D0060681biological_processbranch elongation involved in ureteric bud branching
D0070374biological_processpositive regulation of ERK1 and ERK2 cascade
D0072163biological_processmesonephric epithelium development
D1901509biological_processregulation of endothelial tube morphogenesis
D1902533biological_processpositive regulation of intracellular signal transduction
D1903672biological_processpositive regulation of sprouting angiogenesis
D2000347biological_processpositive regulation of hepatocyte proliferation
D2000544biological_processregulation of endothelial cell chemotaxis to fibroblast growth factor
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 150
ChainResidue
AASN18
ALYS112
ALYS113
ALYS118
AHOH159

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 B 150
ChainResidue
BHOH158
BASN18
BLYS112
BLYS113
BLYS118

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 C 150
ChainResidue
CASN18
CLYS112
CLYS113
CLYS118

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 D 150
ChainResidue
DASN18
DLYS112
DLYS113
DLYS118

Functional Information from PROSITE/UniProt
site_idPS00247
Number of Residues24
DetailsHBGF_FGF HBGF/FGF family signature. GlLyGsqtpne.EClFlErleenhY
ChainResidueDetails
AGLY71-TYR94

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:11069186, ECO:0000269|PubMed:9655399
ChainResidueDetails
AASN18
BASN18
CASN18
DASN18

219140

PDB entries from 2024-05-01

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