2ACT
CRYSTALLOGRAPHIC REFINEMENT OF THE STRUCTURE OF ACTINIDIN AT 1.7 ANGSTROMS RESOLUTION BY FAST FOURIER LEAST-SQUARES METHODS
Replaces: 1ACTFunctional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NH4 A 221 |
| Chain | Residue |
| A | GLU52 |
| A | ASP80 |
| A | ILE83 |
| A | ASN84 |
| A | LEU102 |
| A | GLN103 |
| A | GLN105 |
| A | LYS106 |
| site_id | CAT |
| Number of Residues | 5 |
| Details | CATALYTIC RESIDUES AND THOSE INTIMATELY ASSOCIATED WITH THEM |
| Chain | Residue |
| A | CSD25 |
| A | HIS162 |
| A | ASN182 |
| A | GLN19 |
| A | TRP184 |
| site_id | S2 |
| Number of Residues | 6 |
| Details | RESIDUES MAKING UP THE NON-POLAR BINDING POCKET FOR A SUBSTRATE (S2 SUB-SITE) |
| Chain | Residue |
| A | ALA163 |
| A | MET211 |
| A | TYR69 |
| A | ILE70 |
| A | ALA136 |
| A | VAL160 |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGeCGGCWAfSA |
| Chain | Residue | Details |
| A | GLN19-ALA30 |
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. VDHAIVIVGYG |
| Chain | Residue | Details |
| A | VAL160-GLY170 |
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWIvKNSWdttWGeeGYMrI |
| Chain | Residue | Details |
| A | TYR177-ILE196 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10088","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1606141","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1AEC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10089","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10090","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"1606141","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AEC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | ASN182 | |
| A | HIS162 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | GLN19 | |
| A | HIS162 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | ASN182 | |
| A | GLN19 | |
| A | HIS162 |
