2ABA

Structure of reduced PETN reductase in complex with progesterone

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0010181	molecular_function	FMN binding
A	0016491	molecular_function	oxidoreductase activity
A	0016628	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE FMN A 1401

Chain	Residue
A	ALA23
A	GLY301
A	ALA302
A	GLY323
A	ARG324
A	TYR351
A	STR1500
A	HOH1511
A	HOH1523
A	HOH1595
A	HOH1754
A	PRO24
A	HOH2172
A	LEU25
A	THR26
A	ALA58
A	GLN100
A	HIS181
A	HIS184
A	ARG233

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE STR A 1500

Chain	Residue
A	THR26
A	TYR68
A	HIS91
A	ARG142
A	HIS181
A	HIS184
A	TYR186
A	GLN241
A	TYR351
A	FMN1401
A	IPA1501
A	IPA1502
A	HOH1757

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE IPA A 1501

Chain	Residue
A	ALA140
A	ILE141
A	ARG142
A	TYR351
A	STR1500
A	HOH1765
A	HOH2115

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE IPA A 1502

Chain	Residue
A	HIS184
A	ASP274
A	LEU275
A	STR1500
A	HOH1903

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"11428899","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11923299","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11428899","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11923299","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15128738","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19891489","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21064170","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21374779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28177310","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GVR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GVS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H50","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H51","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H60","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H61","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H63","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VYP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VYR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VYS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KFT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P67","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P81","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P84","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P8I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P8J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11428899","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11923299","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15128738","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16156787","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19891489","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21064170","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21374779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28177310","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31119061","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GVR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GVS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H50","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H51","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H60","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H61","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H63","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VYP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VYR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VYS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ABA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ABB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KFT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P81","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P84","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P8I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P8J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11428899","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11923299","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15128738","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16156787","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19891489","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21064170","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21374779","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28177310","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31119061","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GVR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1GVS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H50","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H51","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H60","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H61","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H63","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VYP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VYR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1VYS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ABA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ABB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KFT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P67","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P74","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P80","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P81","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P82","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P84","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P8I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P8J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16156787","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2ABA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11428899","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16156787","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1H60","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ABA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1oya

Chain	Residue	Details
A	HIS181
A	TYR186
A	HIS184

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1oya

Chain	Residue	Details
A	GLU272
A	TYR186

---