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2AB6

HUMAN GLUTATHIONE S-TRANSFERASE M2-2 (E.C.2.5.1.18) complexed with S-METHYLGLUTATHIONE

Functional Information from GO Data
ChainGOidnamespacecontents
A0004364molecular_functionglutathione transferase activity
A0004602molecular_functionglutathione peroxidase activity
A0005102molecular_functionsignaling receptor binding
A0005504molecular_functionfatty acid binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006629biological_processlipid metabolic process
A0006749biological_processglutathione metabolic process
A0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
A0016529cellular_componentsarcoplasmic reticulum
A0016740molecular_functiontransferase activity
A0018916biological_processnitrobenzene metabolic process
A0019899molecular_functionenzyme binding
A0042178biological_processxenobiotic catabolic process
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043295molecular_functionglutathione binding
A0043651biological_processlinoleic acid metabolic process
A0045171cellular_componentintercellular bridge
A0051122biological_processhepoxilin biosynthetic process
A0055119biological_processrelaxation of cardiac muscle
A0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
A0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
A0070062cellular_componentextracellular exosome
A0070458biological_processcellular detoxification of nitrogen compound
A0071313biological_processcellular response to caffeine
A0098869biological_processcellular oxidant detoxification
B0004364molecular_functionglutathione transferase activity
B0004602molecular_functionglutathione peroxidase activity
B0005102molecular_functionsignaling receptor binding
B0005504molecular_functionfatty acid binding
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006629biological_processlipid metabolic process
B0006749biological_processglutathione metabolic process
B0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
B0016529cellular_componentsarcoplasmic reticulum
B0016740molecular_functiontransferase activity
B0018916biological_processnitrobenzene metabolic process
B0019899molecular_functionenzyme binding
B0042178biological_processxenobiotic catabolic process
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043295molecular_functionglutathione binding
B0043651biological_processlinoleic acid metabolic process
B0045171cellular_componentintercellular bridge
B0051122biological_processhepoxilin biosynthetic process
B0055119biological_processrelaxation of cardiac muscle
B0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
B0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
B0070062cellular_componentextracellular exosome
B0070458biological_processcellular detoxification of nitrogen compound
B0071313biological_processcellular response to caffeine
B0098869biological_processcellular oxidant detoxification
C0004364molecular_functionglutathione transferase activity
C0004602molecular_functionglutathione peroxidase activity
C0005102molecular_functionsignaling receptor binding
C0005504molecular_functionfatty acid binding
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006629biological_processlipid metabolic process
C0006749biological_processglutathione metabolic process
C0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
C0016529cellular_componentsarcoplasmic reticulum
C0016740molecular_functiontransferase activity
C0018916biological_processnitrobenzene metabolic process
C0019899molecular_functionenzyme binding
C0042178biological_processxenobiotic catabolic process
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043295molecular_functionglutathione binding
C0043651biological_processlinoleic acid metabolic process
C0045171cellular_componentintercellular bridge
C0051122biological_processhepoxilin biosynthetic process
C0055119biological_processrelaxation of cardiac muscle
C0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
C0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
C0070062cellular_componentextracellular exosome
C0070458biological_processcellular detoxification of nitrogen compound
C0071313biological_processcellular response to caffeine
C0098869biological_processcellular oxidant detoxification
D0004364molecular_functionglutathione transferase activity
D0004602molecular_functionglutathione peroxidase activity
D0005102molecular_functionsignaling receptor binding
D0005504molecular_functionfatty acid binding
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006629biological_processlipid metabolic process
D0006749biological_processglutathione metabolic process
D0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
D0016529cellular_componentsarcoplasmic reticulum
D0016740molecular_functiontransferase activity
D0018916biological_processnitrobenzene metabolic process
D0019899molecular_functionenzyme binding
D0042178biological_processxenobiotic catabolic process
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043295molecular_functionglutathione binding
D0043651biological_processlinoleic acid metabolic process
D0045171cellular_componentintercellular bridge
D0051122biological_processhepoxilin biosynthetic process
D0055119biological_processrelaxation of cardiac muscle
D0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
D0060316biological_processpositive regulation of ryanodine-sensitive calcium-release channel activity
D0070062cellular_componentextracellular exosome
D0070458biological_processcellular detoxification of nitrogen compound
D0071313biological_processcellular response to caffeine
D0098869biological_processcellular oxidant detoxification
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE GSM A 1218
ChainResidue
ATYR6
AGLN71
ASER72
AHOH1223
BASP105
ATRP7
ALEU12
AARG42
ATRP45
ALYS49
AASN58
ALEU59
APRO60

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE GSM B 2218
ChainResidue
AASP105
BTYR6
BTRP7
BLEU12
BARG42
BTRP45
BLYS49
BASN58
BLEU59
BPRO60
BGLN71
BSER72
BHOH2221
BHOH2258

site_idAC3
Number of Residues15
DetailsBINDING SITE FOR RESIDUE GSM C 3218
ChainResidue
CTYR6
CTRP7
CLEU12
CARG42
CTRP45
CLYS49
CASN58
CLEU59
CPRO60
CGLN71
CSER72
CHOH3238
CHOH3248
CHOH3253
DASP105

site_idAC4
Number of Residues14
DetailsBINDING SITE FOR RESIDUE GSM D 4218
ChainResidue
CASP105
CHOH3221
DTYR6
DTRP7
DLEU12
DARG42
DTRP45
DLYS49
DASN58
DLEU59
DPRO60
DGLN71
DSER72
DHOH4225

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:16549767, ECO:0000269|PubMed:19808963
ChainResidueDetails
ATRP7
CSER43
CLEU59
CSER72
DTRP7
DSER43
DLEU59
DSER72
ASER43
ALEU59
ASER72
BTRP7
BSER43
BLEU59
BSER72
CTRP7

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P08010
ChainResidueDetails
APHE50
BPHE50
CPHE50
DPHE50

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AASP116
BASP116
CASP116
DASP116

site_idSWS_FT_FI4
Number of Residues4
DetailsSITE: Important for substrate specificity
ChainResidueDetails
ALYS210
BLYS210
CLYS210
DLYS210

site_idSWS_FT_FI5
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P08010
ChainResidueDetails
ATYR27
AGLN44
BTYR27
BGLN44
CTYR27
CGLN44
DTYR27
DGLN44

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
ATYR6

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
BTYR6

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
CTYR6

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1oe8
ChainResidueDetails
DTYR6

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PDB entries from 2024-07-17

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