2A9H

NMR structural studies of a potassium channel / charybdotoxin complex

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0005576	cellular_component	extracellular region
E	0008200	molecular_function	ion channel inhibitor activity
E	0015459	molecular_function	potassium channel regulator activity
E	0031640	biological_process	killing of cells of another organism
E	0035821	biological_process	modulation of process of another organism
E	0042742	biological_process	defense response to bacterium
E	0050832	biological_process	defense response to fungus
E	0090729	molecular_function	toxin activity
E	0099106	molecular_function	ion channel regulator activity

Functional Information from PROSITE/UniProt

site_id	PS01138
Number of Residues	23
Details	SCORP_SHORT_TOXIN Scorpion short toxins signature. CwsvCqrlhntsr.GKCMnkkCrC

Chain	Residue	Details
E	CYS813-CYS835

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Basic residue of the functional dyad => ECO:0000250

Chain	Residue	Details
E	LYS827
B	MET1-ARG27
C	MET1-ARG27
D	MET1-ARG27

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Aromatic residue of the functional dyad => ECO:0000250

Chain	Residue	Details
E	TYR836
A	GLY88-ALA111
B	ALA28-ALA50
B	GLY88-ALA111
C	ALA28-ALA50
C	GLY88-ALA111
D	ALA28-ALA50
D	GLY88-ALA111

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269|PubMed:2453055, ECO:0000269|PubMed:2482078

Chain	Residue	Details
E	PCA801
A	LEU81-TRP87
B	GLU51-SER61
B	LEU81-TRP87
C	GLU51-SER61
C	LEU81-TRP87
D	GLU51-SER61
D	LEU81-TRP87

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site_id	SWS_FT_FI4
Number of Residues	40
Details	INTRAMEM: Helical; Pore-forming

Chain	Residue	Details
A	TYR62-THR72
B	TYR62-THR72
C	TYR62-THR72
D	TYR62-THR72

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site_id	SWS_FT_FI5
Number of Residues	28
Details	INTRAMEM: Pore-forming

Chain	Residue	Details
A	ALA73-ASP80
B	ALA73-ASP80
C	ALA73-ASP80
D	ALA73-ASP80

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