2A9H
NMR structural studies of a potassium channel / charybdotoxin complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005249 | molecular_function | voltage-gated potassium channel activity |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0008076 | cellular_component | voltage-gated potassium channel complex |
| B | 0005249 | molecular_function | voltage-gated potassium channel activity |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0008076 | cellular_component | voltage-gated potassium channel complex |
| C | 0005249 | molecular_function | voltage-gated potassium channel activity |
| C | 0006813 | biological_process | potassium ion transport |
| C | 0008076 | cellular_component | voltage-gated potassium channel complex |
| D | 0005249 | molecular_function | voltage-gated potassium channel activity |
| D | 0006813 | biological_process | potassium ion transport |
| D | 0008076 | cellular_component | voltage-gated potassium channel complex |
| E | 0005576 | cellular_component | extracellular region |
| E | 0008200 | molecular_function | ion channel inhibitor activity |
| E | 0015459 | molecular_function | potassium channel regulator activity |
| E | 0031640 | biological_process | killing of cells of another organism |
| E | 0035821 | biological_process | modulation of process of another organism |
| E | 0042742 | biological_process | defense response to bacterium |
| E | 0050832 | biological_process | defense response to fungus |
| E | 0090729 | molecular_function | toxin activity |
| E | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from PROSITE/UniProt
| site_id | PS01138 |
| Number of Residues | 23 |
| Details | SCORP_SHORT_TOXIN Scorpion short toxins signature. CwsvCqrlhntsr.GKCMnkkCrC |
| Chain | Residue | Details |
| E | CYS813-CYS835 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | SITE: Basic residue of the functional dyad => ECO:0000250 |
| Chain | Residue | Details |
| E | LYS827 | |
| B | MET1-ARG27 | |
| C | MET1-ARG27 | |
| D | MET1-ARG27 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Aromatic residue of the functional dyad => ECO:0000250 |
| Chain | Residue | Details |
| E | TYR836 | |
| A | GLY88-ALA111 | |
| B | ALA28-ALA50 | |
| B | GLY88-ALA111 | |
| C | ALA28-ALA50 | |
| C | GLY88-ALA111 | |
| D | ALA28-ALA50 | |
| D | GLY88-ALA111 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269|PubMed:2453055, ECO:0000269|PubMed:2482078 |
| Chain | Residue | Details |
| E | PCA801 | |
| A | LEU81-TRP87 | |
| B | GLU51-SER61 | |
| B | LEU81-TRP87 | |
| C | GLU51-SER61 | |
| C | LEU81-TRP87 | |
| D | GLU51-SER61 | |
| D | LEU81-TRP87 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 40 |
| Details | INTRAMEM: Helical; Pore-forming |
| Chain | Residue | Details |
| A | TYR62-THR72 | |
| B | TYR62-THR72 | |
| C | TYR62-THR72 | |
| D | TYR62-THR72 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 28 |
| Details | INTRAMEM: Pore-forming |
| Chain | Residue | Details |
| A | ALA73-ASP80 | |
| B | ALA73-ASP80 | |
| C | ALA73-ASP80 | |
| D | ALA73-ASP80 |
