Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001666 | biological_process | response to hypoxia |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0015035 | molecular_function | protein-disulfide reductase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019430 | biological_process | removal of superoxide radicals |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0070402 | molecular_function | NADPH binding |
| B | 0001666 | biological_process | response to hypoxia |
| B | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0015035 | molecular_function | protein-disulfide reductase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019430 | biological_process | removal of superoxide radicals |
| B | 0045454 | biological_process | cell redox homeostasis |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0070402 | molecular_function | NADPH binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 336 |
| Chain | Residue |
| A | HIS250 |
| A | ARG295 |
| A | NAP381 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 336 |
| Chain | Residue |
| B | HIS250 |
| B | ARG295 |
| B | NAP481 |
| site_id | AC3 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE FAD A 348 |
| Chain | Residue |
| A | PRO24 |
| A | ALA25 |
| A | PHE43 |
| A | GLU44 |
| A | GLY45 |
| A | SER47 |
| A | GLY49 |
| A | GLY50 |
| A | ALA51 |
| A | LEU52 |
| A | THR55 |
| A | VAL58 |
| A | GLU59 |
| A | ASN60 |
| A | GLU91 |
| A | ASP92 |
| A | VAL93 |
| A | ALA121 |
| A | MET122 |
| A | GLY123 |
| A | CYS148 |
| A | ASP149 |
| A | ARG253 |
| A | LEU256 |
| A | GLY287 |
| A | ASP288 |
| A | ARG295 |
| A | GLN296 |
| A | ALA297 |
| A | VAL298 |
| A | HOH385 |
| A | HOH387 |
| B | TYR32 |
| A | GLY21 |
| A | SER22 |
| A | GLY23 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE NAP A 381 |
| Chain | Residue |
| A | ARG127 |
| A | LEU129 |
| A | GLY164 |
| A | ASP165 |
| A | SER166 |
| A | HIS185 |
| A | ARG186 |
| A | ARG187 |
| A | ARG191 |
| A | ILE248 |
| A | GLY249 |
| A | PRO265 |
| A | TYR268 |
| A | LEU270 |
| A | ARG292 |
| A | ARG295 |
| A | MG336 |
| B | ARG313 |
| site_id | AC5 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE FAD B 448 |
| Chain | Residue |
| A | TYR32 |
| B | ILE20 |
| B | GLY21 |
| B | SER22 |
| B | PRO24 |
| B | ALA25 |
| B | PHE43 |
| B | GLU44 |
| B | GLY45 |
| B | SER47 |
| B | PHE48 |
| B | GLY49 |
| B | GLY50 |
| B | ALA51 |
| B | LEU52 |
| B | THR55 |
| B | ASN60 |
| B | VAL93 |
| B | MET122 |
| B | GLY123 |
| B | ALA124 |
| B | CYS148 |
| B | ASP149 |
| B | ARG253 |
| B | LEU256 |
| B | GLY287 |
| B | ASP288 |
| B | ARG295 |
| B | GLN296 |
| B | ALA297 |
| B | VAL298 |
| site_id | AC6 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE NAP B 481 |
| Chain | Residue |
| B | ARG186 |
| B | ARG191 |
| B | ALA247 |
| B | ILE248 |
| B | GLY249 |
| B | GLU251 |
| B | TYR268 |
| B | ARG292 |
| B | ARG295 |
| B | MG336 |
| B | ILE161 |
| B | GLY162 |
| B | GLY163 |
| B | GLY164 |
| B | ASP165 |
| B | SER166 |
| B | GLU169 |
| B | HIS185 |
Functional Information from PROSITE/UniProt
| site_id | PS00573 |
| Number of Residues | 21 |
| Details | PYRIDINE_REDOX_2 Pyridine nucleotide-disulphide oxidoreductases class-II active site. CatCDGff..FrdqdIaVIGGGD |
| Chain | Residue | Details |
| A | CYS145-ASP165 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | SER22 | |
| A | ASP288 | |
| A | ARG295 | |
| B | SER22 | |
| B | GLU44 | |
| B | ASN60 | |
| B | VAL93 | |
| B | SER166 | |
| B | HIS185 | |
| B | ARG191 | |
| B | ILE248 | |
| A | GLU44 | |
| B | TYR268 | |
| B | ASP288 | |
| B | ARG295 | |
| A | ASN60 | |
| A | VAL93 | |
| A | SER166 | |
| A | HIS185 | |
| A | ARG191 | |
| A | ILE248 | |
| A | TYR268 | |
| Chain | Residue | Details |
| A | THR2 | |
| B | THR2 | |
| Chain | Residue | Details |
| A | TYR32 | |
| B | TYR32 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1tde |
| Chain | Residue | Details |
| A | CYS145 | |
| A | CYS148 | |
| A | ASP149 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1tde |
| Chain | Residue | Details |
| B | CYS145 | |
| B | CYS148 | |
| B | ASP149 | |
