2A79
Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002244 | biological_process | hematopoietic progenitor cell differentiation |
| A | 0004033 | molecular_function | aldo-keto reductase (NADPH) activity |
| A | 0005249 | molecular_function | voltage-gated potassium channel activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005874 | cellular_component | microtubule |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0008076 | cellular_component | voltage-gated potassium channel complex |
| A | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| A | 0014069 | cellular_component | postsynaptic density |
| A | 0015459 | molecular_function | potassium channel regulator activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0030424 | cellular_component | axon |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034702 | cellular_component | monoatomic ion channel complex |
| A | 0034705 | cellular_component | potassium channel complex |
| A | 0043005 | cellular_component | neuron projection |
| A | 0043194 | cellular_component | axon initial segment |
| A | 0043679 | cellular_component | axon terminus |
| A | 0044224 | cellular_component | juxtaparanode region of axon |
| A | 0044325 | molecular_function | transmembrane transporter binding |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0045202 | cellular_component | synapse |
| A | 0045445 | biological_process | myoblast differentiation |
| A | 0050905 | biological_process | neuromuscular process |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0055114 | biological_process | obsolete oxidation-reduction process |
| A | 0070995 | biological_process | NADPH oxidation |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| A | 0098839 | cellular_component | postsynaptic density membrane |
| A | 0098900 | biological_process | regulation of action potential |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 1901379 | biological_process | regulation of potassium ion transmembrane transport |
| A | 1990031 | cellular_component | pinceau fiber |
| A | 2000008 | biological_process | regulation of protein localization to cell surface |
| B | 0001508 | biological_process | action potential |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005249 | molecular_function | voltage-gated potassium channel activity |
| B | 0005251 | molecular_function | delayed rectifier potassium channel activity |
| B | 0005267 | molecular_function | potassium channel activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005768 | cellular_component | endosome |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0008076 | cellular_component | voltage-gated potassium channel complex |
| B | 0014059 | biological_process | regulation of dopamine secretion |
| B | 0015271 | molecular_function | outward rectifier potassium channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0019228 | biological_process | neuronal action potential |
| B | 0019233 | biological_process | sensory perception of pain |
| B | 0019894 | molecular_function | kinesin binding |
| B | 0021554 | biological_process | optic nerve development |
| B | 0021633 | biological_process | optic nerve structural organization |
| B | 0021987 | biological_process | cerebral cortex development |
| B | 0022038 | biological_process | corpus callosum development |
| B | 0030027 | cellular_component | lamellipodium |
| B | 0030424 | cellular_component | axon |
| B | 0030425 | cellular_component | dendrite |
| B | 0031258 | cellular_component | lamellipodium membrane |
| B | 0032809 | cellular_component | neuronal cell body membrane |
| B | 0033010 | cellular_component | paranodal junction |
| B | 0034702 | cellular_component | monoatomic ion channel complex |
| B | 0034705 | cellular_component | potassium channel complex |
| B | 0042734 | cellular_component | presynaptic membrane |
| B | 0043005 | cellular_component | neuron projection |
| B | 0043194 | cellular_component | axon initial segment |
| B | 0043204 | cellular_component | perikaryon |
| B | 0043679 | cellular_component | axon terminus |
| B | 0044224 | cellular_component | juxtaparanode region of axon |
| B | 0044305 | cellular_component | calyx of Held |
| B | 0045188 | biological_process | regulation of circadian sleep/wake cycle, non-REM sleep |
| B | 0045202 | cellular_component | synapse |
| B | 0045211 | cellular_component | postsynaptic membrane |
| B | 0051260 | biological_process | protein homooligomerization |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0060078 | biological_process | regulation of postsynaptic membrane potential |
| B | 0070161 | cellular_component | anchoring junction |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 0097623 | biological_process | potassium ion export across plasma membrane |
| B | 0098978 | cellular_component | glutamatergic synapse |
| B | 0099505 | biological_process | regulation of presynaptic membrane potential |
| B | 0099508 | molecular_function | voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential |
| B | 1905030 | molecular_function | voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE K B 500 |
| Chain | Residue |
| B | GLY376 |
| B | K501 |
| B | K501 |
| B | K501 |
| B | GLY376 |
| B | GLY376 |
| B | GLY376 |
| B | TYR377 |
| B | TYR377 |
| B | TYR377 |
| B | TYR377 |
| B | K501 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE K B 501 |
| Chain | Residue |
| B | VAL375 |
| B | VAL375 |
| B | VAL375 |
| B | VAL375 |
| B | GLY376 |
| B | GLY376 |
| B | GLY376 |
| B | GLY376 |
| B | K500 |
| B | K500 |
| B | K500 |
| B | K500 |
| B | K502 |
| B | K502 |
| B | K502 |
| B | K502 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE K B 502 |
| Chain | Residue |
| B | THR374 |
| B | THR374 |
| B | THR374 |
| B | THR374 |
| B | VAL375 |
| B | VAL375 |
| B | VAL375 |
| B | VAL375 |
| B | K501 |
| B | K501 |
| B | K501 |
| B | K501 |
| B | K503 |
| B | K503 |
| B | K503 |
| B | K503 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE K B 503 |
| Chain | Residue |
| B | THR374 |
| B | THR374 |
| B | THR374 |
| B | THR374 |
| B | K502 |
| B | K502 |
| B | K502 |
| B | K502 |
| site_id | AC5 |
| Number of Residues | 31 |
| Details | BINDING SITE FOR RESIDUE NAP A 1001 |
| Chain | Residue |
| A | GLY55 |
| A | THR56 |
| A | TRP57 |
| A | GLN63 |
| A | ASP85 |
| A | TYR90 |
| A | LYS118 |
| A | ASN158 |
| A | SER188 |
| A | ARG189 |
| A | GLN214 |
| A | TRP243 |
| A | SER244 |
| A | PRO245 |
| A | LEU246 |
| A | ALA247 |
| A | CYS248 |
| A | GLY249 |
| A | SER252 |
| A | LYS254 |
| A | ARG264 |
| A | LEU321 |
| A | GLY323 |
| A | SER325 |
| A | GLN329 |
| A | GLU332 |
| A | ASN333 |
| A | HOH530 |
| A | HOH547 |
| A | HOH548 |
| A | HOH580 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 183 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430 |
| Chain | Residue | Details |
| B | MET1-GLY160 | |
| B | CYS244-ILE254 | |
| B | SER311-MET325 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=Segment S1 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430 |
| Chain | Residue | Details |
| B | PRO161-LEU182 | |
| A | LYS254 | |
| A | ARG264 | |
| A | SER325 | |
| A | GLN329 | |
| A | ASN333 | |
| A | SER244 | |
| A | LEU246 | |
| A | TRP57 | |
| A | GLN63 | |
| A | ASP85 | |
| A | SER188 | |
| A | GLN214 | |
| A | TRP243 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 38 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430, ECO:0000305|PubMed:12151401 |
| Chain | Residue | Details |
| B | GLU183-PRO221 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=Segment S2 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430 |
| Chain | Residue | Details |
| B | PHE222-ALA243 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=Segment S3 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20534430 |
| Chain | Residue | Details |
| B | MET255-ALA275 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 32 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430 |
| Chain | Residue | Details |
| B | GLU276-SER289 | |
| B | PHE348-ILE361 | |
| B | PRO382-LYS388 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20534430 |
| Chain | Residue | Details |
| B | LEU290-HIS310 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=Segment S5 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430 |
| Chain | Residue | Details |
| B | ARG326-TYR347 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 11 |
| Details | INTRAMEM: Helical; Name=Pore helix => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430 |
| Chain | Residue | Details |
| B | PRO362-THR373 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 7 |
| Details | INTRAMEM: INTRAMEM => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430 |
| Chain | Residue | Details |
| B | THR374-VAL381 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=Segment S6 => ECO:0000269|PubMed:18004376, ECO:0000269|PubMed:20360102, ECO:0000269|PubMed:20534430 |
| Chain | Residue | Details |
| B | ILE389-TYR417 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 81 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:12151401, ECO:0000305 |
| Chain | Residue | Details |
| B | HIS418-VAL499 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | SITE: Important for normal, slow channel gating => ECO:0000269|PubMed:17766348 |
| Chain | Residue | Details |
| B | THR252 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | SITE: Important for binding with the scorpion mesomartoxin; when the scorpion mesomartoxin-rKv1.2/KCNA2 interaction is modeled, this residue is close to the 'Y-57' residue of the toxin => ECO:0000305|PubMed:25514171 |
| Chain | Residue | Details |
| B | VAL381 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P63141 |
| Chain | Residue | Details |
| B | TYR429 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P63141 |
| Chain | Residue | Details |
| B | SER434 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:18003609, ECO:0007744|PubMed:22673903 |
| Chain | Residue | Details |
| B | SER440 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903 |
| Chain | Residue | Details |
| B | SER441 | |
| B | SER468 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:18003609, ECO:0000269|PubMed:21602278 |
| Chain | Residue | Details |
| B | SER449 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000305|PubMed:21602278 |
| Chain | Residue | Details |
| B | TYR458 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000255 |
| Chain | Residue | Details |
| B | CYS244 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:16770729 |
| Chain | Residue | Details |
| B | ASN207 |
