Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2A65

Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016021	cellular_component	integral component of membrane
A	0005886	cellular_component	plasma membrane
A	0005328	molecular_function	neurotransmitter:sodium symporter activity

Functional Information from PDB Data

site_id

Number of Residues

Details

AC1

BINDING SITE FOR RESIDUE BOG A 701

Chain	Residue
A	LEU53
A	ARG142
A	GLU146
A	PRO445
A	ARG446
A	TYR448
A	HOH837
A	HOH876
A	HOH932
A	HOH941

AC2

BINDING SITE FOR RESIDUE BOG A 702

Chain	Residue
A	LEU166
A	PHE167
A	ILE170
A	ARG438
A	GLY439
A	GLY440
A	HOH928

AC3

BINDING SITE FOR RESIDUE BOG A 703

Chain	Residue
A	PRO164
A	LEU166
A	TYR169
A	HIS391
A	PHE395
A	BOG704
A	HOH884
A	HOH1006

AC4

BINDING SITE FOR RESIDUE BOG A 704

Chain	Residue
A	LYS163
A	HIS391
A	LEU392
A	PHE395
A	TRP484
A	PHE488
A	BOG703
A	BOG705
A	HOH972

AC5

BINDING SITE FOR RESIDUE BOG A 705

Chain	Residue
A	ILE161
A	PHE395
A	LYS431
A	MET476
A	GLU477
A	GLU478
A	THR479
A	TRP481
A	VAL483
A	TRP484
A	ILE485
A	ARG487
A	BOG704

AC6

BINDING SITE FOR RESIDUE NA A 751

Chain	Residue
A	GLY20
A	VAL23
A	GLY24
A	ALA351
A	THR354
A	SER355

AC7

BINDING SITE FOR RESIDUE NA A 752

Chain	Residue
A	ALA22
A	ASN27
A	THR254
A	ASN286
A	LEU601

AC8

BINDING SITE FOR RESIDUE CL A 753

Chain	Residue
A	TYR151
A	SER165

AC9

BINDING SITE FOR RESIDUE LEU A 601

Chain	Residue
A	ASN21
A	ALA22
A	GLY24
A	LEU25
A	GLY26
A	ASN27
A	TYR108
A	PHE253
A	THR254
A	SER256
A	PHE259
A	NA752

Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_id

Number of Residues

Details

LEU_2a65_A_601

LEUCINE binding site

Chain	Residue	ligand
A	ASN21-ASN27	LEU: LEUCINE
A	VAL104	LEU: LEUCINE
A	TYR108	LEU: LEUCINE
A	PHE253-SER256	LEU: LEUCINE
A	PHE259	LEU: LEUCINE
A	ASN286	LEU: LEUCINE
A	SER355	LEU: LEUCINE
A	ILE359	LEU: LEUCINE

BOG_2a65_A_701

B-OCTYLGLUCOSIDE binding site

Chain	Residue	ligand
A	LEU52-LEU53	BOG: B-OCTYLGLUCOSIDE
A	PRO445-TYR448	BOG: B-OCTYLGLUCOSIDE
A	VAL451	BOG: B-OCTYLGLUCOSIDE

BOG_2a65_A_702

B-OCTYLGLUCOSIDE binding site

Chain	Residue	ligand
A	ILE120	BOG: B-OCTYLGLUCOSIDE
A	LEU166-PHE167	BOG: B-OCTYLGLUCOSIDE
A	ILE170	BOG: B-OCTYLGLUCOSIDE
A	ILE174	BOG: B-OCTYLGLUCOSIDE

BOG_2a65_A_705

B-OCTYLGLUCOSIDE binding site

Chain	Residue	ligand
A	ILE161	BOG: B-OCTYLGLUCOSIDE
A	LEU392	BOG: B-OCTYLGLUCOSIDE
A	PHE395-LEU396	BOG: B-OCTYLGLUCOSIDE
A	ILE485	BOG: B-OCTYLGLUCOSIDE

BOG_2a65_A_704

B-OCTYLGLUCOSIDE binding site

Chain	Residue	ligand
A	LEU162-PRO164	BOG: B-OCTYLGLUCOSIDE
A	HIS391-LEU392	BOG: B-OCTYLGLUCOSIDE
A	PHE395	BOG: B-OCTYLGLUCOSIDE

BOG_2a65_A_703

B-OCTYLGLUCOSIDE binding site

Chain	Residue	ligand
A	LYS163-LEU166	BOG: B-OCTYLGLUCOSIDE
A	TYR169	BOG: B-OCTYLGLUCOSIDE
A	PHE387-PHE388	BOG: B-OCTYLGLUCOSIDE
A	HIS391	BOG: B-OCTYLGLUCOSIDE
A	PHE395	BOG: B-OCTYLGLUCOSIDE