2A5V

Crystal structure of M. tuberculosis beta carbonic anhydrase, Rv3588c, tetrameric form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004089	molecular_function	carbonate dehydratase activity
A	0005515	molecular_function	protein binding
A	0008270	molecular_function	zinc ion binding
A	0015976	biological_process	carbon utilization
A	0016829	molecular_function	lyase activity
A	0046872	molecular_function	metal ion binding
B	0004089	molecular_function	carbonate dehydratase activity
B	0005515	molecular_function	protein binding
B	0008270	molecular_function	zinc ion binding
B	0015976	biological_process	carbon utilization
B	0016829	molecular_function	lyase activity
B	0046872	molecular_function	metal ion binding
C	0004089	molecular_function	carbonate dehydratase activity
C	0005515	molecular_function	protein binding
C	0008270	molecular_function	zinc ion binding
C	0015976	biological_process	carbon utilization
C	0016829	molecular_function	lyase activity
C	0046872	molecular_function	metal ion binding
D	0004089	molecular_function	carbonate dehydratase activity
D	0005515	molecular_function	protein binding
D	0008270	molecular_function	zinc ion binding
D	0015976	biological_process	carbon utilization
D	0016829	molecular_function	lyase activity
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SCN A 501

Chain	Residue
A	CYS51
A	ASP53
A	HIS104
A	CYS107
A	GLY108
A	ZN401

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 401

Chain	Residue
A	SCN501
A	CYS51
A	HIS104
A	CYS107

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN A 405

Chain	Residue
A	HIS-3
A	HIS0

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN A 409

Chain	Residue
A	HIS158
A	ASP198

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN A 400

Chain	Residue
A	HIS-4
A	HIS-2

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SCN B 502

Chain	Residue
A	TYR89
B	ASP53
B	HIS104
B	CYS107
B	GLY108
B	ZN402

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 402

Chain	Residue
B	CYS51
B	HIS104
B	CYS107
B	SCN502

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN B 408

Chain	Residue
B	HIS-2
B	HIS0

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SCN C 503

Chain	Residue
C	CYS51
C	ASP53
C	HIS104
C	CYS107
C	GLY108
C	ZN403

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SCN C 504

Chain	Residue
C	GLN42
D	ASP53
D	ALA75

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 403

Chain	Residue
C	CYS51
C	HIS104
C	CYS107
C	SCN503

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN D 404

Chain	Residue
D	CYS51
D	HIS104
D	CYS107

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN D 406

Chain	Residue
D	HIS-3
D	HIS-1

---

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN D 407

Chain	Residue
D	HIS-2
D	HIS0

---

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN D 410

Chain	Residue
D	HIS158
D	ASP198

---

Functional Information from PROSITE/UniProt

site_id	PS00704
Number of Residues	8
Details	PROK_CO2_ANHYDRASE_1 Prokaryotic-type carbonic anhydrases signature 1. CADSRVaA

Chain	Residue	Details
A	CYS51-ALA58

---

site_id	PS00705
Number of Residues	21
Details	PROK_CO2_ANHYDRASE_2 Prokaryotic-type carbonic anhydrases signature 2. EYAVtvLnvplIVVlGHdsCG

Chain	Residue	Details
A	GLU88-GLY108

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:15753099, ECO:0000269|PubMed:16321983, ECO:0007744|PDB:1YM3, ECO:0007744|PDB:2A5V

Chain	Residue	Details
A	CYS51
D	CYS51
D	HIS104
D	CYS107
A	HIS104
A	CYS107
B	CYS51
B	HIS104
B	CYS107
C	CYS51
C	HIS104
C	CYS107

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:15753099, ECO:0007744|PDB:1YM3

Chain	Residue	Details
A	ASP53
B	ASP53
C	ASP53
D	ASP53

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1i6p

Chain	Residue	Details
A	ASP53
A	ARG55

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1i6p

Chain	Residue	Details
B	ASP53
B	ARG55

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1i6p

Chain	Residue	Details
C	ASP53
C	ARG55

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1i6p

Chain	Residue	Details
D	ASP53
D	ARG55

---