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2A5E

SOLUTION NMR STRUCTURE OF TUMOR SUPPRESSOR P16INK4A, RESTRAINED MINIMIZED MEAN STRUCTURE

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001953biological_processnegative regulation of cell-matrix adhesion
A0003723molecular_functionRNA binding
A0004861molecular_functioncyclin-dependent protein serine/threonine kinase inhibitor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0007265biological_processRas protein signal transduction
A0008285biological_processnegative regulation of cell population proliferation
A0008544biological_processepidermis development
A0009303biological_processrRNA transcription
A0010468biological_processregulation of gene expression
A0019901molecular_functionprotein kinase binding
A0030216biological_processkeratinocyte differentiation
A0030308biological_processnegative regulation of cell growth
A0033598biological_processmammary gland epithelial cell proliferation
A0033600biological_processnegative regulation of mammary gland epithelial cell proliferation
A0034393biological_processpositive regulation of smooth muscle cell apoptotic process
A0035019biological_processsomatic stem cell population maintenance
A0035985cellular_componentsenescence-associated heterochromatin focus
A0042593biological_processglucose homeostasis
A0043616biological_processkeratinocyte proliferation
A0045736biological_processnegative regulation of cyclin-dependent protein serine/threonine kinase activity
A0045786biological_processnegative regulation of cell cycle
A0045892biological_processnegative regulation of DNA-templated transcription
A0046822biological_processregulation of nucleocytoplasmic transport
A0051059molecular_functionNF-kappaB binding
A0051726biological_processregulation of cell cycle
A0060057biological_processapoptotic process involved in mammary gland involution
A0060058biological_processpositive regulation of apoptotic process involved in mammary gland involution
A0070301biological_processcellular response to hydrogen peroxide
A0090398biological_processcellular senescence
A0090399biological_processreplicative senescence
A0090402biological_processoncogene-induced cell senescence
A1903051biological_processnegative regulation of proteolysis involved in protein catabolic process
A2000045biological_processregulation of G1/S transition of mitotic cell cycle
A2000059biological_processnegative regulation of ubiquitin-dependent protein catabolic process
A2000111biological_processpositive regulation of macrophage apoptotic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues29
DetailsRepeat: {"description":"ANK 1"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues28
DetailsRepeat: {"description":"ANK 2"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues29
DetailsRepeat: {"description":"ANK 3"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues29
DetailsRepeat: {"description":"ANK 4"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"12529334","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

239803

PDB entries from 2025-08-06

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