2A4Q

HCV NS3 protease with NS4a peptide and a covalently bound macrocyclic ketoamide compound.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003724	molecular_function	RNA helicase activity
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0019028	cellular_component	viral capsid
A	0019062	biological_process	virion attachment to host cell
A	0019087	biological_process	symbiont-mediated transformation of host cell
A	0033644	cellular_component	host cell membrane
A	0043657	cellular_component	host cell
A	0044423	cellular_component	virion component
A	0046718	biological_process	symbiont entry into host cell
A	0046872	molecular_function	metal ion binding
A	0055036	cellular_component	virion membrane
A	0097264	biological_process	self proteolysis
C	0003724	molecular_function	RNA helicase activity
C	0006508	biological_process	proteolysis
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0016787	molecular_function	hydrolase activity
C	0019028	cellular_component	viral capsid
C	0019062	biological_process	virion attachment to host cell
C	0019087	biological_process	symbiont-mediated transformation of host cell
C	0033644	cellular_component	host cell membrane
C	0043657	cellular_component	host cell
C	0044423	cellular_component	virion component
C	0046718	biological_process	symbiont entry into host cell
C	0046872	molecular_function	metal ion binding
C	0055036	cellular_component	virion membrane
C	0097264	biological_process	self proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 301

Chain	Residue
A	CYS97
A	CYS99
A	CYS145
A	HOH433

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 302

Chain	Residue
C	CYS97
C	CYS99
C	CYS145
C	HOH303

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BME A 201

Chain	Residue
A	CYS16
A	ILE17
A	THR38
A	LEU13

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site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE FNH A 401

Chain	Residue
A	GLN41
A	THR42
A	HIS57
A	LEU135
A	LYS136
A	GLY137
A	SER138
A	SER139
A	ARG155
A	ALA156
A	ALA157
A	CYS159
A	ASP168

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1rgq

Chain	Residue	Details
A	ASP81
A	SER139
A	GLY137
A	HIS57

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site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1rgq

Chain	Residue	Details
C	ASP81
C	SER139
C	GLY137
C	HIS57

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