2A3R

Crystal Structure of Human Sulfotransferase SULT1A3 in Complex with Dopamine and 3-Phosphoadenosine 5-Phosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004062	molecular_function	aryl sulfotransferase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006068	biological_process	ethanol catabolic process
A	0006584	biological_process	catecholamine metabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0008146	molecular_function	sulfotransferase activity
A	0008202	biological_process	steroid metabolic process
A	0009812	biological_process	flavonoid metabolic process
A	0016740	molecular_function	transferase activity
A	0042417	biological_process	dopamine metabolic process
A	0042420	biological_process	dopamine catabolic process
A	0043199	molecular_function	sulfate binding
A	0047685	molecular_function	amine sulfotransferase activity
A	0050427	biological_process	3'-phosphoadenosine 5'-phosphosulfate metabolic process
A	0051923	biological_process	sulfation
A	1903351	biological_process	cellular response to dopamine
B	0004062	molecular_function	aryl sulfotransferase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006068	biological_process	ethanol catabolic process
B	0006584	biological_process	catecholamine metabolic process
B	0006805	biological_process	xenobiotic metabolic process
B	0008146	molecular_function	sulfotransferase activity
B	0008202	biological_process	steroid metabolic process
B	0009812	biological_process	flavonoid metabolic process
B	0016740	molecular_function	transferase activity
B	0042417	biological_process	dopamine metabolic process
B	0042420	biological_process	dopamine catabolic process
B	0043199	molecular_function	sulfate binding
B	0047685	molecular_function	amine sulfotransferase activity
B	0050427	biological_process	3'-phosphoadenosine 5'-phosphosulfate metabolic process
B	0051923	biological_process	sulfation
B	1903351	biological_process	cellular response to dopamine

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE A3P A 296

Chain	Residue
A	LYS48
A	THR227
A	SER228
A	PHE229
A	MET232
A	PHE255
A	MET256
A	ARG257
A	LYS258
A	GLY259
A	HOH310
A	SER49
A	HOH313
A	HOH317
A	HOH343
A	GLY50
A	THR51
A	THR52
A	TRP53
A	ARG130
A	SER138
A	TYR193

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE LDP A 297

Chain	Residue
A	PHE24
A	PRO47
A	PHE81
A	ASP86
A	LYS106
A	HIS108
A	GLU146
A	ALA148
A	HIS149

---

site_id	AC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE A3P B 296

Chain	Residue
B	LYS48
B	SER49
B	GLY50
B	THR51
B	THR52
B	TRP53
B	ARG130
B	SER138
B	TYR193
B	THR227
B	SER228
B	PHE229
B	MET232
B	PHE255
B	MET256
B	ARG257
B	LYS258
B	GLY259
B	HOH300
B	HOH309
B	HOH316
B	HOH333

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE LDP B 297

Chain	Residue
B	PHE24
B	PRO47
B	PHE81
B	ASP86
B	LYS106
B	HIS108
B	GLU146
B	ALA148
B	HIS149

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P49888

Chain	Residue	Details
A	HIS108
B	HIS108

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:16083857, ECO:0007744|PDB:2A3R

Chain	Residue	Details
A	LYS48
B	LYS48
B	ASP86
B	LYS106
B	ARG130
B	SER138
B	GLU146
B	TYR193
B	THR227
B	ARG257
A	ASP86
A	LYS106
A	ARG130
A	SER138
A	GLU146
A	TYR193
A	THR227
A	ARG257

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