2A3K

Crystal Structure of the Human Protein Tyrosine Phosphatase, PTPN7 (HePTP, Hematopoietic Protein Tyrosine Phosphatase)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0006470	biological_process	protein dephosphorylation
A	0016311	biological_process	dephosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 A 501

Chain	Residue
A	HOH14
A	GLN335
A	ASP257
A	CYS291
A	SER292
A	ALA293
A	GLY294
A	ILE295
A	GLY296
A	ARG297

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 A 502

Chain	Residue
A	HOH17
A	THR195
A	GLN196
A	SER292
A	ARG297

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 A 503

Chain	Residue
A	PRO81
A	LEU82
A	THR83
A	ALA86
A	SER263
A	ALA264
A	GLY265
A	HIS345
A	LEU349
A	PO4504

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 A 504

Chain	Residue
A	HIS80
A	GLY265
A	PO4503

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Functional Information from PROSITE/UniProt

site_id	PS00383
Number of Residues	11
Details	TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGigRTG

Chain	Residue	Details
A	VAL289-GLY299

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044, ECO:0000269|PubMed:9624114

Chain	Residue	Details
A	CYS291

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
A	ASP257
A	CYS291
A	GLN335

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:10206983, ECO:0007744|PubMed:18088087, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	THR66

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:10206983

Chain	Residue	Details
A	SER93

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER110

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER143

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Cysteine sulfenic acid (-SOH) => ECO:0000250

Chain	Residue	Details
A	CYS291

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	5
Details	Annotated By Reference To The Literature 1ytw

Chain	Residue	Details
A	CYS291
A	ASP257
A	THR298
A	ARG297
A	HIS290

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1ytw

Chain	Residue	Details
A	CYS291
A	ASP257
A	THR298
A	ARG297

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