29QL
FKBP12 in complex with bifunctional ligand a1d and the second bromodomain of BRD4
This is a non-PDB format compatible entry.
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Site: {"description":"Acetylated histone binding","evidences":[{"source":"PubMed","id":"22464331","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 176 |
| Details | Domain: {"description":"PPIase FKBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P26883","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 362 |
| Chain | Residue | Details |
| C | TYR26 | electrostatic destabiliser, steric role |
| C | PHE36 | electrostatic destabiliser, polar/non-polar interaction, steric role |
| C | ASP37 | electrostatic stabiliser, steric role |
| C | ILE56 | electrostatic stabiliser, steric role |
| C | TYR82 | electrostatic stabiliser, steric role |
| C | PHE99 | electrostatic destabiliser, polar/non-polar interaction, steric role |
| site_id | MCSA2 |
| Number of Residues | 6 |
| Details | M-CSA 362 |
| Chain | Residue | Details |
| D | TYR26 | electrostatic destabiliser, steric role |
| D | PHE36 | electrostatic destabiliser, polar/non-polar interaction, steric role |
| D | ASP37 | electrostatic stabiliser, steric role |
| D | ILE56 | electrostatic stabiliser, steric role |
| D | TYR82 | electrostatic stabiliser, steric role |
| D | PHE99 | electrostatic destabiliser, polar/non-polar interaction, steric role |
