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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

23FC

Cryo-EM structure of human ATR-ATRIP complex with ATPgammaS and Chk1

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues72
DetailsRepeat: {"description":"HEAT 1"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues72
DetailsRepeat: {"description":"HEAT 2"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues64
DetailsDomain: {"description":"FATC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00534","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU00535","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues12
DetailsRegion: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues16
DetailsRegion: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues48
DetailsRegion: {"description":"Activation loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"PubMed","id":"21705319","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21777809","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues14
DetailsMotif: {"description":"EEXXXDL motif"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by ATM and ATR","evidences":[{"source":"PubMed","id":"11390642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12446774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12588868","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12660173","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12676583","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12676962","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14657349","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15707391","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15870257","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

253795

PDB entries from 2026-05-20

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