22BK
KCNQ2/3 heterotetramer with 2:2 stoichiometry
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"PubMed","id":"32884139","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CR3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 56 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"PubMed","id":"32884139","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CR3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 56 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 38 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"source":"PubMed","id":"32884139","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CR3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 36 |
| Details | Transmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"PubMed","id":"32884139","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CR3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 50 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"PubMed","id":"32884139","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CR3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 24 |
| Details | Intramembrane: {"description":"Pore-forming; Name=Segment H5","evidences":[{"source":"PubMed","id":"32884139","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CR3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 52 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"PubMed","id":"32884139","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CR3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 202 |
| Details | Region: {"description":"Mediates interaction with SLC5A3/SMIT1","evidences":[{"source":"UniProtKB","id":"O88943","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | Motif: {"description":"Selectivity filter","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37857637","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8J01","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8W4U","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37857637","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8W4U","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"16319223","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"UniProtKB","id":"O43526","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 38 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"UniProtKB","id":"O43526","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 56 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 36 |
| Details | Transmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"UniProtKB","id":"O43526","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 50 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"UniProtKB","id":"O43526","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 24 |
| Details | Intramembrane: {"description":"Pore-forming; Name=Segment H5","evidences":[{"source":"UniProtKB","id":"O43526","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 52 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"UniProtKB","id":"O43526","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"O43526","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
