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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

21VV

Cryo-EM structure of ncBAF bound to the nucleosome

Functional Information from GO Data
ChainGOidnamespacecontents
A0000786cellular_componentnucleosome
A0005634cellular_componentnucleus
A0005694cellular_componentchromosome
A0006334biological_processnucleosome assembly
A0030527molecular_functionstructural constituent of chromatin
B0000786cellular_componentnucleosome
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005694cellular_componentchromosome
B0006334biological_processnucleosome assembly
B0030527molecular_functionstructural constituent of chromatin
B0031507biological_processheterochromatin formation
C0000786cellular_componentnucleosome
C0005634cellular_componentnucleus
C0005694cellular_componentchromosome
C0030527molecular_functionstructural constituent of chromatin
C0031507biological_processheterochromatin formation
D0000786cellular_componentnucleosome
D0002227biological_processinnate immune response in mucosa
D0003677molecular_functionDNA binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005694cellular_componentchromosome
D0006325biological_processchromatin organization
D0019731biological_processantibacterial humoral response
D0030527molecular_functionstructural constituent of chromatin
D0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
E0000786cellular_componentnucleosome
E0005634cellular_componentnucleus
E0005694cellular_componentchromosome
E0006334biological_processnucleosome assembly
E0030527molecular_functionstructural constituent of chromatin
F0000786cellular_componentnucleosome
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005694cellular_componentchromosome
F0006334biological_processnucleosome assembly
F0030527molecular_functionstructural constituent of chromatin
F0031507biological_processheterochromatin formation
G0000786cellular_componentnucleosome
G0005634cellular_componentnucleus
G0005694cellular_componentchromosome
G0030527molecular_functionstructural constituent of chromatin
G0031507biological_processheterochromatin formation
H0000786cellular_componentnucleosome
H0002227biological_processinnate immune response in mucosa
H0003677molecular_functionDNA binding
H0005576cellular_componentextracellular region
H0005634cellular_componentnucleus
H0005694cellular_componentchromosome
H0006325biological_processchromatin organization
H0019731biological_processantibacterial humoral response
H0030527molecular_functionstructural constituent of chromatin
H0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
I0000166molecular_functionnucleotide binding
I0001650cellular_componentfibrillar center
I0003677molecular_functionDNA binding
I0003713molecular_functiontranscription coactivator activity
I0004386molecular_functionhelicase activity
I0005524molecular_functionATP binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005730cellular_componentnucleolus
I0006338biological_processchromatin remodeling
I0008094molecular_functionATP-dependent activity, acting on DNA
I0016514cellular_componentSWI/SNF complex
I0016787molecular_functionhydrolase activity
I0030308biological_processnegative regulation of cell growth
I0045893biological_processpositive regulation of DNA-templated transcription
J0000776cellular_componentkinetochore
J0000785cellular_componentchromatin
J0000786cellular_componentnucleosome
J0000930cellular_componentgamma-tubulin complex
J0001738biological_processmorphogenesis of a polarized epithelium
J0005200molecular_functionstructural constituent of cytoskeleton
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0005856cellular_componentcytoskeleton
J0005884cellular_componentactin filament
J0005886cellular_componentplasma membrane
J0005903cellular_componentbrush border
J0005911cellular_componentcell-cell junction
J0005912cellular_componentadherens junction
J0005925cellular_componentfocal adhesion
J0006338biological_processchromatin remodeling
J0006357biological_processregulation of transcription by RNA polymerase II
J0007010biological_processcytoskeleton organization
J0007020biological_processmicrotubule nucleation
J0007163biological_processestablishment or maintenance of cell polarity
J0007409biological_processaxonogenesis
J0008284biological_processpositive regulation of cell population proliferation
J0015629cellular_componentactin cytoskeleton
J0016020cellular_componentmembrane
J0016363cellular_componentnuclear matrix
J0016514cellular_componentSWI/SNF complex
J0016586cellular_componentRSC-type complex
J0016887molecular_functionATP hydrolysis activity
J0019894molecular_functionkinesin binding
J0019901molecular_functionprotein kinase binding
J0021762biological_processsubstantia nigra development
J0030027cellular_componentlamellipodium
J0030071biological_processregulation of mitotic metaphase/anaphase transition
J0030235molecular_functionnitric-oxide synthase regulator activity
J0030424cellular_componentaxon
J0030863cellular_componentcortical cytoskeleton
J0030957molecular_functionTat protein binding
J0031492molecular_functionnucleosomal DNA binding
J0031982cellular_componentvesicle
J0032991cellular_componentprotein-containing complex
J0034333biological_processadherens junction assembly
J0035060cellular_componentbrahma complex
J0035267cellular_componentNuA4 histone acetyltransferase complex
J0035633biological_processmaintenance of blood-brain barrier
J0036464cellular_componentcytoplasmic ribonucleoprotein granule
J0042802molecular_functionidentical protein binding
J0042981biological_processregulation of apoptotic process
J0043296cellular_componentapical junction complex
J0044305cellular_componentcalyx of Held
J0045176biological_processapical protein localization
J0045202cellular_componentsynapse
J0045582biological_processpositive regulation of T cell differentiation
J0045596biological_processnegative regulation of cell differentiation
J0045597biological_processpositive regulation of cell differentiation
J0045663biological_processpositive regulation of myoblast differentiation
J0045893biological_processpositive regulation of DNA-templated transcription
J0048156molecular_functiontau protein binding
J0048870biological_processcell motility
J0050998molecular_functionnitric-oxide synthase binding
J0051621biological_processregulation of norepinephrine uptake
J0051623biological_processpositive regulation of norepinephrine uptake
J0051726biological_processregulation of cell cycle
J0070062cellular_componentextracellular exosome
J0070160cellular_componenttight junction
J0070316biological_processregulation of G0 to G1 transition
J0070527biological_processplatelet aggregation
J0071564cellular_componentnpBAF complex
J0071565cellular_componentnBAF complex
J0071896biological_processprotein localization to adherens junction
J0072562cellular_componentblood microparticle
J0072749biological_processcellular response to cytochalasin B
J0097433cellular_componentdense body
J0098685cellular_componentSchaffer collateral - CA1 synapse
J0098793cellular_componentpresynapse
J0098871cellular_componentpostsynaptic actin cytoskeleton
J0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
J0098974biological_processpostsynaptic actin cytoskeleton organization
J0098978cellular_componentglutamatergic synapse
J0140092cellular_componentbBAF complex
J0140288cellular_componentGBAF complex
J0141108molecular_functiontransporter regulator activity
J0150111biological_processregulation of transepithelial transport
J1900242biological_processregulation of synaptic vesicle endocytosis
J1902459biological_processpositive regulation of stem cell population maintenance
J1903076biological_processregulation of protein localization to plasma membrane
J1905168biological_processpositive regulation of double-strand break repair via homologous recombination
J1990904cellular_componentribonucleoprotein complex
J2000045biological_processregulation of G1/S transition of mitotic cell cycle
J2000779biological_processregulation of double-strand break repair
J2000781biological_processpositive regulation of double-strand break repair
J2000819biological_processregulation of nucleotide-excision repair
K0000723biological_processtelomere maintenance
K0000776cellular_componentkinetochore
K0000785cellular_componentchromatin
K0000786cellular_componentnucleosome
K0003407biological_processneural retina development
K0003682molecular_functionchromatin binding
K0003713molecular_functiontranscription coactivator activity
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005886cellular_componentplasma membrane
K0006275biological_processregulation of DNA replication
K0006282biological_processregulation of DNA repair
K0006338biological_processchromatin remodeling
K0006355biological_processregulation of DNA-templated transcription
K0006357biological_processregulation of transcription by RNA polymerase II
K0007165biological_processsignal transduction
K0007399biological_processnervous system development
K0008284biological_processpositive regulation of cell population proliferation
K0016363cellular_componentnuclear matrix
K0016514cellular_componentSWI/SNF complex
K0016586cellular_componentRSC-type complex
K0021510biological_processspinal cord development
K0030071biological_processregulation of mitotic metaphase/anaphase transition
K0031011cellular_componentIno80 complex
K0031492molecular_functionnucleosomal DNA binding
K0032991cellular_componentprotein-containing complex
K0033044biological_processregulation of chromosome organization
K0035060cellular_componentbrahma complex
K0035267cellular_componentNuA4 histone acetyltransferase complex
K0042981biological_processregulation of apoptotic process
K0045582biological_processpositive regulation of T cell differentiation
K0045596biological_processnegative regulation of cell differentiation
K0045597biological_processpositive regulation of cell differentiation
K0045663biological_processpositive regulation of myoblast differentiation
K0045739biological_processpositive regulation of DNA repair
K0045893biological_processpositive regulation of DNA-templated transcription
K0045995biological_processregulation of embryonic development
K0048731biological_processsystem development
K0051726biological_processregulation of cell cycle
K0060382biological_processregulation of DNA strand elongation
K0070316biological_processregulation of G0 to G1 transition
K0071564cellular_componentnpBAF complex
K0140288cellular_componentGBAF complex
K1902459biological_processpositive regulation of stem cell population maintenance
K1904507biological_processpositive regulation of telomere maintenance in response to DNA damage
K1905168biological_processpositive regulation of double-strand break repair via homologous recombination
K2000045biological_processregulation of G1/S transition of mitotic cell cycle
K2000779biological_processregulation of double-strand break repair
K2000781biological_processpositive regulation of double-strand break repair
K2000819biological_processregulation of nucleotide-excision repair
N0000785cellular_componentchromatin
N0005515molecular_functionprotein binding
N0005654cellular_componentnucleoplasm
N0006338biological_processchromatin remodeling
N0006357biological_processregulation of transcription by RNA polymerase II
N0008284biological_processpositive regulation of cell population proliferation
N0016514cellular_componentSWI/SNF complex
N0030071biological_processregulation of mitotic metaphase/anaphase transition
N0045596biological_processnegative regulation of cell differentiation
N0045892biological_processnegative regulation of DNA-templated transcription
N0070316biological_processregulation of G0 to G1 transition
N0140288cellular_componentGBAF complex
N1902459biological_processpositive regulation of stem cell population maintenance
N2000045biological_processregulation of G1/S transition of mitotic cell cycle
N2000781biological_processpositive regulation of double-strand break repair
N2000819biological_processregulation of nucleotide-excision repair
Functional Information from PROSITE/UniProt
site_idPS00046
Number of Residues7
DetailsHISTONE_H2A Histone H2A signature. AGLqFPV
ChainResidueDetails
CALA21-VAL27
site_idPS00047
Number of Residues5
DetailsHISTONE_H4 Histone H4 signature. GAKRH
ChainResidueDetails
BGLY14-HIS18
site_idPS00141
Number of Residues12
DetailsASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LILDSGATHTTA
ChainResidueDetails
KLEU168-ALA179
site_idPS00322
Number of Residues7
DetailsHISTONE_H3_1 Histone H3 signature 1. KAPRKQL
ChainResidueDetails
ALYS14-LEU20
site_idPS00357
Number of Residues23
DetailsHISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG
ChainResidueDetails
DARG92-GLY114
site_idPS00406
Number of Residues11
DetailsACTINS_1 Actins signature 1. YVGDEAQs.KRG
ChainResidueDetails
JTYR53-GLY63
site_idPS00432
Number of Residues9
DetailsACTINS_2 Actins signature 2. WISKqEYEE
ChainResidueDetails
KTRP410-GLU418
JTRP356-GLU364
site_idPS00959
Number of Residues9
DetailsHISTONE_H3_2 Histone H3 signature 2. PFqRLVREI
ChainResidueDetails
APRO66-ILE74
site_idPS01132
Number of Residues13
DetailsACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR
ChainResidueDetails
JLEU104-ARG116
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI2
Number of Residues4
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsModified residue: {"description":"N6-propionyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by PAK2","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"N6-methacryllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62805","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"PubMed","id":"30526847","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30626964","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30785395","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31388018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32503840","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsModified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"23673617","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues2
DetailsCross-link: {"description":"(Microbial infection) Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-50); by Vibrio toxins RtxA and VgrG1","evidences":[{"source":"PubMed","id":"19015515","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

256158

PDB entries from 2026-07-08

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